Summary

Name COX4I1
Full Name Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Synonyms Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1 | COX4
Primary ID P13073
Links - -
Type protein
Relations 5
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.743
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COX4I1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization COX4I1 0.367
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COX4I1 0.415
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Oxidative_phosphorylation 0.7
Publications: 1 Organism: Mus Musculus