Summary

Name PPARGC1A
Full Name Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Synonyms PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ligand effect modulator 6 | LEM6, PGC1, PGC1A, PPARGC1
Primary ID Q9UBK2
Links - -
Type protein
Relations 65
Pathways AMPK Signaling, Circadian clock, Myofiber: hypertrophy_cAMP, MTOR Signaling
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PPARGC1A 0.564
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation PPARGC1A 0.48
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Tissue: Skeletal Muscle
Pathways:AMPK Signaling, Circadian clock, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PPARGC1A 0.558
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle, Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation PPARGC1A 0.48
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:AMPK Signaling, Circadian clock, MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation PPARGC1A 0.357
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARGC1A 0.357
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARGC1A 0.463
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARGC1A 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
Pathways:AMPK Signaling, MTOR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPARGC1A 0.407
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARGC1A 0.535
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALDOB 0.248
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NfKb-p65/p50 0.372
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARGC1A 0.898
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock, MTOR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOD2 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPARGC1A 0.324
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NFKB1 0.361
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png deacetylation PPARGC1A 0.792
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:AMPK Signaling, Circadian clock
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARGC1A 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COX4I1 0.415
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO 0.568
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.497
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP7A1 0.448
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation PPARGC1A 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOC3 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COX5B 0.336
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png SOD2 0.387
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png PPARGC1A 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARGC1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOA5 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR1D1 0.5
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYCS 0.395
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OTC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PPARGC1A 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Gluconeogenesis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IGF1 0.351
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png NRF1 0.698
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A4 0.613
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/indirect-activation.png ESRRA 0.92
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARGC1A 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PPARGC1A 0.792
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Circadian clock
+ down-regulates img/indirect_inhibition.png FOXO3 0.407
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARGC1A 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:AMPK Signaling, Circadian clock, MTOR Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARGC1A 0.792
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Circadian clock
+ down-regulates img/indirect_inhibition.png PPARGC1A 0.568
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MSTN 0.374
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by stabilization img/direct-activation.png binding PPARGC1A 0.331
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png GPX1 0.325
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png FOXO 0.568
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO3 0.407
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CAV3 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK2 0.411
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARGC1A 0.261
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.42
Publications: 1 Organism: Chlorocebus Aethiops