| + |
MITRAC complex | up-regulates quantity 
relocalization
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272485 |
|
|
|
|
| pmid |
sentence |
| 23260140 |
Each association relies on the supply of subunits from either the cytosol or the mitochondrial matrix, suggesting that human TIM21 ushers nuclear-encoded proteins to assembly intermediates. In agreement with this, assembly of the early cytochrome c oxidase subunit COX4-1 requires TIM21, whereas it is dispensable for late-assembling subunits. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly. Furthermore, TIM21 appears to be tightly connected to MITRAC15, which, in contrast to TIM23 and MITRAC12, coimmunoprecipitates with TIM21 under all tested conditions. MITRAC15 associates with MITRAC and is required for complex IV but also complex I assembly. |
|
| Publications: |
1 |
| + |
COX14 | form complex 
binding
|
MITRAC complex |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272482 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23260140 |
By analyzing MITRAC12 interaction partners, we show that recently identified assembly factors, such as c12orf62, CMC1, and the novel assembly factor MITRAC15, are constituents of MITRAC complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIMM21 | form complex
binding
|
MITRAC complex |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23260140 |
TIM21 is a constituent of MITRAC and presequence translocase complexes ► TIM21 ushers imported subunits of complexes I and IV to assembly intermediates |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COA1 | form complex
binding
|
MITRAC complex |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272483 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23260140 |
By analyzing MITRAC12 interaction partners, we show that recently identified assembly factors, such as c12orf62, CMC1, and the novel assembly factor MITRAC15, are constituents of MITRAC complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MITRAC complex | up-regulates quantity
relocalization
|
NADH-ubiquinone oxidoreductase-Mitochondrial respiratory chain complex I |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272486 |
|
|
|
|
| pmid |
sentence |
| 23260140 |
Each association relies on the supply of subunits from either the cytosol or the mitochondrial matrix, suggesting that human TIM21 ushers nuclear-encoded proteins to assembly intermediates. In agreement with this, assembly of the early cytochrome c oxidase subunit COX4-1 requires TIM21, whereas it is dispensable for late-assembling subunits. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly. Furthermore, TIM21 appears to be tightly connected to MITRAC15, which, in contrast to TIM23 and MITRAC12, coimmunoprecipitates with TIM21 under all tested conditions. MITRAC15 associates with MITRAC and is required for complex IV but also complex I assembly. |
|
| Publications: |
1 |
| + |
COA3 | form complex
binding
|
MITRAC complex |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272484 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23260140 |
By analyzing MITRAC12 interaction partners, we show that recently identified assembly factors, such as c12orf62, CMC1, and the novel assembly factor MITRAC15, are constituents of MITRAC complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CMC1 | form complex
binding
|
MITRAC complex |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272481 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23260140 |
By analyzing MITRAC12 interaction partners, we show that recently identified assembly factors, such as c12orf62, CMC1, and the novel assembly factor MITRAC15, are constituents of MITRAC complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MITRAC complex | up-regulates quantity
relocalization
|
COX4I1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272487 |
|
|
|
|
| pmid |
sentence |
| 23260140 |
Each association relies on the supply of subunits from either the cytosol or the mitochondrial matrix, suggesting that human TIM21 ushers nuclear-encoded proteins to assembly intermediates. In agreement with this, assembly of the early cytochrome c oxidase subunit COX4-1 requires TIM21, whereas it is dispensable for late-assembling subunits. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly. Furthermore, TIM21 appears to be tightly connected to MITRAC15, which, in contrast to TIM23 and MITRAC12, coimmunoprecipitates with TIM21 under all tested conditions. MITRAC15 associates with MITRAC and is required for complex IV but also complex I assembly. |
|
| Publications: |
1 |
4.0
MITRAC complex