+ |
COX6A1 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.723 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267747 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
MT-CO2 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.758 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267748 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX8A | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.508 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267753 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX7A2 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.499 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267741 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX5A | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.796 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267751 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX4I1 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.745 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267744 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
MT-CO1 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.662 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267746 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
MITRAC complex | up-regulates quantity
relocalization
|
Mitochondrial respiratory chain complex IV |
0.31 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272485 |
|
|
|
|
pmid |
sentence |
23260140 |
Each association relies on the supply of subunits from either the cytosol or the mitochondrial matrix, suggesting that human TIM21 ushers nuclear-encoded proteins to assembly intermediates. In agreement with this, assembly of the early cytochrome c oxidase subunit COX4-1 requires TIM21, whereas it is dispensable for late-assembling subunits. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly. Furthermore, TIM21 appears to be tightly connected to MITRAC15, which, in contrast to TIM23 and MITRAC12, coimmunoprecipitates with TIM21 under all tested conditions. MITRAC15 associates with MITRAC and is required for complex IV but also complex I assembly. |
|
Publications: |
1 |
+ |
NDUFA4 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.523 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267752 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX6B1 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.748 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267742 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
MT-CO3 | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.673 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267743 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX7C | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.772 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267754 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX5B | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.787 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267749 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
COX7B | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.653 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267745 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
Mitochondrial respiratory chain complex IV | up-regulates
|
Respiratory electron transport chain |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262140 |
|
|
|
|
pmid |
sentence |
30030361 |
The oxidative phosphorylation system (OXPHOS) of the mitochondrial inner membrane is composed of five enzymes (complexes I–V; cI–V). In mammals, they are all multimeric and, except for cII, have subunits encoded both in the mitochondrial genome (mtDNA) and the nuclear genome (nDNA). |
|
Publications: |
1 |
+ |
COX6C | form complex
binding
|
Mitochondrial respiratory chain complex IV |
0.739 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267750 |
|
|
|
|
pmid |
sentence |
30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
Publications: |
1 |
+ |
Inner_mitochondrial_membrane | up-regulates
relocalization
|
Mitochondrial respiratory chain complex IV |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267008 |
|
|
Homo sapiens |
|
pmid |
sentence |
25627476 |
One of the main functions of the IMM is the housing of proteins that make up the electron transport chain (ETC) which ultimately produces ATP. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LETM1 | up-regulates
|
Mitochondrial respiratory chain complex IV |
0.294 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262548 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
18628306 |
LETM1 knockdown obviously reduced the formation of the supercomplexes (Fig. 5C, arrowhead). Complexes I and IV failed to form, and the assembly of complex III was significantly decreased. By contrast, the assembly of complex II (succinate dehydrogenase) and complex V (ATP synthase) – which are not proton pumps – was unaffected. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |