Relation Results

Summary

Name Mitochondrial respiratory chain complex IV
Primary ID SIGNOR-C280
Links CPX-6123
Type complex
Formed by COX6C, COX5A, NDUFA4, COX8A, COX7A2, COX6A1, MT-CO2, COX5B, COX7B, COX7C, COX6B1, MT-CO3, COX4I1, MT-CO1
Relations 18

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Type: Score: Layout: SPV 
0.7640.6710.5210.7540.8010.750.3060.7290.20.6620.7450.490.70.7920.2920.7770.5360.68MT-CO2Mitochondrial respiratory chain complex IVMT-CO1COX8ACOX6B1COX5ACOX4I1MITRAC complexCOX6A1Inner_mitochondrial_membraneCOX7BCOX6CCOX7A2Respiratory electron transport chainCOX5BLETM1COX7CNDUFA4MT-CO3

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Relations
Regulator
Mechanism
target
score ℹ
+ MT-CO2form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.764
Identifier Residue Sequence Organism Cell Line
SIGNOR-267748
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ MT-CO1form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.671
Identifier Residue Sequence Organism Cell Line
SIGNOR-267746
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ COX8Aform complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.521
Identifier Residue Sequence Organism Cell Line
SIGNOR-267753
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ COX6B1form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.754
Identifier Residue Sequence Organism Cell Line
SIGNOR-267742
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ COX5Aform complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.801
Identifier Residue Sequence Organism Cell Line
SIGNOR-267751
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ COX4I1form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.75
Identifier Residue Sequence Organism Cell Line
SIGNOR-267744
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ MITRAC complexup-regulates quantity img/direct-activation.png relocalization Mitochondrial respiratory chain complex IV 0.306
Identifier Residue Sequence Organism Cell Line
SIGNOR-272485
pmid sentence
Each association relies on the supply of subunits from either the cytosol or the mitochondrial matrix, suggesting that human TIM21 ushers nuclear-encoded proteins to assembly intermediates. In agreement with this, assembly of the early cytochrome c oxidase subunit COX4-1 requires TIM21, whereas it is dispensable for late-assembling subunits. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly. Furthermore, TIM21 appears to be tightly connected to MITRAC15, which, in contrast to TIM23 and MITRAC12, coimmunoprecipitates with TIM21 under all tested conditions. MITRAC15 associates with MITRAC and is required for complex IV but also complex I assembly.
Publications: 1
+ COX6A1form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.729
Identifier Residue Sequence Organism Cell Line
SIGNOR-267747
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ Inner_mitochondrial_membraneup-regulates img/direct-activation.png relocalization Mitochondrial respiratory chain complex IV 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267008 Homo sapiens
pmid sentence
One of the main functions of the IMM is the housing of proteins that make up the electron transport chain (ETC) which ultimately produces ATP. 
Publications: 1 Organism: Homo Sapiens
+ COX7Bform complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.662
Identifier Residue Sequence Organism Cell Line
SIGNOR-267745
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ COX6Cform complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.745
Identifier Residue Sequence Organism Cell Line
SIGNOR-267750
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ COX7A2form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.49
Identifier Residue Sequence Organism Cell Line
SIGNOR-267741
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ Mitochondrial respiratory chain complex IVup-regulates img/indirect-activation.png Respiratory electron transport chain 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-262140
pmid sentence
The oxidative phosphorylation system (OXPHOS) of the mitochondrial inner membrane is composed of five enzymes (complexes I–V; cI–V). In mammals, they are all multimeric and, except for cII, have subunits encoded both in the mitochondrial genome (mtDNA) and the nuclear genome (nDNA).
Publications: 1
+ COX5Bform complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.792
Identifier Residue Sequence Organism Cell Line
SIGNOR-267749
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ LETM1up-regulates img/indirect-activation.png Mitochondrial respiratory chain complex IV 0.292
Identifier Residue Sequence Organism Cell Line
SIGNOR-262548 Homo sapiens HeLa Cell
pmid sentence
LETM1 knockdown obviously reduced the formation of the supercomplexes (Fig. 5C, arrowhead). Complexes I and IV failed to form, and the assembly of complex III was significantly decreased. By contrast, the assembly of complex II (succinate dehydrogenase) and complex V (ATP synthase) – which are not proton pumps – was unaffected.
Publications: 1 Organism: Homo Sapiens
+ COX7Cform complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.777
Identifier Residue Sequence Organism Cell Line
SIGNOR-267754
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ NDUFA4form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.536
Identifier Residue Sequence Organism Cell Line
SIGNOR-267752
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
+ MT-CO3form complex img/form-complex.png binding Mitochondrial respiratory chain complex IV 0.68
Identifier Residue Sequence Organism Cell Line
SIGNOR-267743
pmid sentence
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits
Publications: 1
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