| + |
Inner_mitochondrial_membrane | up-regulates 
relocalization
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25627476 |
One of the main functions of the IMM is the housing of proteins that make up the electron transport chain (ETC) which ultimately produces ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MT-CO1 | form complex 
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267746 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
MITRAC complex | up-regulates quantity
relocalization
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272485 |
|
|
|
|
| pmid |
sentence |
| 23260140 |
Each association relies on the supply of subunits from either the cytosol or the mitochondrial matrix, suggesting that human TIM21 ushers nuclear-encoded proteins to assembly intermediates. In agreement with this, assembly of the early cytochrome c oxidase subunit COX4-1 requires TIM21, whereas it is dispensable for late-assembling subunits. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly. Furthermore, TIM21 appears to be tightly connected to MITRAC15, which, in contrast to TIM23 and MITRAC12, coimmunoprecipitates with TIM21 under all tested conditions. MITRAC15 associates with MITRAC and is required for complex IV but also complex I assembly. |
|
| Publications: |
1 |
| + |
COX6B1 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267742 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX7B | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267745 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX5A | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267751 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX7A2 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267741 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
MT-CO3 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267743 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX6A1 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267747 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX5B | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267749 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX4I1 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267744 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX7C | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267754 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV | up-regulates 
|
Respiratory electron transport chain |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262140 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
The oxidative phosphorylation system (OXPHOS) of the mitochondrial inner membrane is composed of five enzymes (complexes I–V; cI–V). In mammals, they are all multimeric and, except for cII, have subunits encoded both in the mitochondrial genome (mtDNA) and the nuclear genome (nDNA). |
|
| Publications: |
1 |
| + |
COX6C | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267750 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
COX8A | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267753 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
LETM1 | up-regulates
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262548 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18628306 |
LETM1 knockdown obviously reduced the formation of the supercomplexes (Fig. 5C, arrowhead). Complexes I and IV failed to form, and the assembly of complex III was significantly decreased. By contrast, the assembly of complex II (succinate dehydrogenase) and complex V (ATP synthase) – which are not proton pumps – was unaffected. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV | up-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV | down-regulates quantity 
chemical modification
|
dioxygen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280294 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV | up-regulates quantity
chemical modification
|
water |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYCS | up-regulates activity
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIM8A-TIM13 mitochondrial intermembrane space protein transporter complex | up-regulates activity
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281387 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37272231 |
We demonstrate that hTim8a and hTim8b function in the assembly of cytochrome c oxidase (Complex IV). Using affinity enrichment mass spectrometry, we define the interaction network of hTim8a, hTim8b and hTim13, identifying subunits and assembly factors of the Complex IV COX2 module. These data suggest that hTim8a and hTim8b function in assembly of Complex IV via interactions with intermediate-assembly subcomplexes. We propose that hTim8-hTim13 complexes are auxiliary assembly factors involved in the formation of the Complex IV S3 subcomplex during assembly of mature Complex IV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIM8B-TIM13 mitochondrial intermembrane space protein transporter complex | up-regulates activity
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37272231 |
We demonstrate that hTim8a and hTim8b function in the assembly of cytochrome c oxidase (Complex IV). Using affinity enrichment mass spectrometry, we define the interaction network of hTim8a, hTim8b and hTim13, identifying subunits and assembly factors of the Complex IV COX2 module. These data suggest that hTim8a and hTim8b function in assembly of Complex IV via interactions with intermediate-assembly subcomplexes. We propose that hTim8-hTim13 complexes are auxiliary assembly factors involved in the formation of the Complex IV S3 subcomplex during assembly of mature Complex IV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NDUFA4 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267752 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
| + |
MT-CO2 | form complex
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267748 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex IV (EC 1.9.31) or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation [108]. Mammalian cIV contains 13 or 14 subunits |
|
| Publications: |
1 |
4.0
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV
CPX-6123