Summary

Name OSM
Full Name Oncostatin-M
Synonyms OSM
Primary ID P13725
Links - -
Type protein
Relations 4
Function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding IL6ST 0.741
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates img/direct-activation.png binding OSMR 0.786
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LIFR 0.715
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AHR 0.349
Publications: 1 Organism: Homo Sapiens