| + |
MAPK3 | down-regulates 
phosphorylation
|
LIFR |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-32757 |
Ser1044 |
WNLVSPDsPRSIDSN |
Homo sapiens |
|
| pmid |
sentence |
| 7777512 |
Thus, our results identify the human lifr as a substrate for mapk and suggest a mechanism of heterologous receptor regulation of lifr signaling occurring at ser-1044. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates
phosphorylation
|
LIFR |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-32753 |
Ser1044 |
WNLVSPDsPRSIDSN |
Homo sapiens |
|
| pmid |
sentence |
| 7777512 |
Indeed, phosphorylation of the cytoplasmic domain of the low-affinity lif receptor alpha-subunit (lifr) in mono q-fractionated, lif-stimulated 3t3-l1 extracts occurred only in those fractions containing activated mapk;ser-1044 served as the major phosphorylation site in the human lifr for mapk both in agonist-stimulated 3t3-l1 lysates and by recombinant extracellular signal-regulated kinase 2 in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAM3C | up-regulates activity 
binding
|
LIFR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277986 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 35680099 |
Interleukin-like EMT inducer (ILEI) a cytokine from the FAM3 family, also functions as a ligand for LIFR-gp130 heterodimer and mediates intracellular signal through STAT activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OSM | up-regulates
binding
|
LIFR |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19873 |
|
|
Homo sapiens |
Macrophage, Leukemia Cell |
| pmid |
sentence |
| 1536831 |
Oncostatin m binds the high-affinity leukemia inhibitory factor receptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
Gbeta | down-regulates
phosphorylation
|
LIFR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7777512 |
Thus, our results identify the human lifr as a substrate for mapk and suggest a mechanism of heterologous receptor regulation of lifr signaling occurring at ser-1044. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LIF | up-regulates
binding
|
LIFR |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204847 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Lif binds at low-affinity to lifr, the structure of which is closely related to that of gp130 (42). Lifr then becomes heterodimerized with gp130 to form the high-affinity and signaling-competent complex (43). Osm utilizes this type of heterodimer, i.e. the lifr/gp130 complex (43, 44). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051226 |
Lif binds at low-affinity to lifr, the structure of which is closely related to that of gp130 (42). Lifr then becomes heterodimerized with gp130 to form the high-affinity and signaling-competent complex (43). Osm utilizes this type of heterodimer, i.e. the lifr/gp130 complex (43, 44). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
LIFR | up-regulates
binding
|
IL6ST |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
CNTF | up-regulates
binding
|
LIFR |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10966616 |
Ciliary neurotrophic factor (cntf) is a cytokine supporting the differentiation and survival of various cell types in the peripheral and central nervous systems. Its receptor complex consists of a non-signaling alpha chain, cntfr, and two signaling beta chains, gp130 and the leukemia inhibitory factor receptor (lifr) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTF1 | up-regulates
binding
|
LIFR |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114758 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11834704 |
We conclude that gp130/lif receptor and et(a) receptor activation are essential for cardiac fibroblast growth by ct-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
ERK1/2 | down-regulates
phosphorylation
|
LIFR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7777512 |
Thus, our results identify the human lifr as a substrate for mapk and suggest a mechanism of heterologous receptor regulation of lifr signaling occurring at ser-1044. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
mifepristone | down-regulates activity
chemical modification
|
LIFR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278032 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 36359879 |
In conclusion, we identified a LIF/LIFR pathway that promotes/maintains oncogenicity in PDAC cell lines. Using docking and pharmacological experiments, we have shown that mifepristone, a clinically approved anti-steroidal agent, functions as a LIFR antagonist, directly binding the LIFR complex and preventing its activation in PDAC cell lines. Present results support the repositioning of mifepristone in the treatment of LIFR expressing PDAC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LIFR
- 
- 