| + |
CRHR1 | up-regulates quantity by expression 
transcriptional regulation
|
Corticotropin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268613 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23504413 |
CRH, as a principal mediator of endocrine stress response, activates the HPA axis (Hypothalamic–pituitary–adrenal axis) by binding to the CRHR1 in the anterior pituitary. This, through a cascade of reactions, increases the expression of proopiomelanocortin (POMC) gene and the subsequent release of POMC-derived peptides, adrenocorticotropic hormone (ACTH) and β-endorphin. ACTH, in turn, stimulates the secretion of glucocorticoids from adrenal cortex (Vale et al. 1981). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| + |
Corticotropin | up-regulates activity 
binding
|
MC5R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
PCSK1 | up-regulates quantity
cleavage
|
Corticotropin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268724 |
|
|
|
|
| pmid |
sentence |
| 24631756 |
POMC is post-translationally cleaved by prohormone convertase enzymes 1 and 2 (PC1, PC2) into ACTH, an N-terminal glycopeptide |
|
| Publications: |
1 |
| + |
progesterone | down-regulates 
|
Corticotropin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268727 |
|
|
|
|
| pmid |
sentence |
| 24631756 |
ACTH and corticosterone responses to the same acute stress stimulus are higher in the pro-estrus phase of the cycle, when the serum concentrations of estrogen are the highest (Viau and Meaney, 1991). In the same study, it was shown that progesterone inhibits the sensitizing effects of estrogen on ACTH release during stress, as the ACTH levels and HPA output decreased with increasing amounts of progesterone in the estrous and diestrous phases. |
|
| Publications: |
1 |
| + |
PCSK2 | up-regulates quantity
cleavage
|
Corticotropin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268725 |
|
|
|
|
| pmid |
sentence |
| 24631756 |
POMC is post-translationally cleaved by prohormone convertase enzymes 1 and 2 (PC1, PC2) into ACTH, an N-terminal glycopeptide |
|
| Publications: |
1 |
| + |
Corticotropin | up-regulates quantity
|
HSD3B1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24631756 |
CTH signaling promotes the single steroidogenic rate limiting step, which is the conversion of cholesterol to pregnenolone by Cholesterol Side-Chain Cleavage Enzyme (P450scc), encoded in the CYP11A1 gene. This is conferred by a direct stimulating effect of ACTH on the promoter of CYP11A1 (Chung et al., 1997, Liu and Simpson, 1997, Hu et al., 2001). Further, it stimulates conversion of pregnenolone to 17-hydroxypregnenolone by upregulating the expression of 3β hydroxysteroid dehydrogenase enzyme (3β-HSD) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Corticotropin | up-regulates activity
binding
|
MC2R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268616 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 20371771 |
Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate (cAMP). |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Tissue: |
Adrenal Gland |
| + |
Corticotropin | up-regulates activity
binding
|
MC1R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268701 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Corticotropin | up-regulates activity
binding
|
MC3R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Corticotropin | up-regulates activity
binding
|
MC4R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268711 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Corticotropin | up-regulates quantity
|
CYP11A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24631756 |
CTH signaling promotes the single steroidogenic rate limiting step, which is the conversion of cholesterol to pregnenolone by Cholesterol Side-Chain Cleavage Enzyme (P450scc), encoded in the CYP11A1 gene. This is conferred by a direct stimulating effect of ACTH on the promoter of CYP11A1 (Chung et al., 1997, Liu and Simpson, 1997, Hu et al., 2001). Further, it stimulates conversion of pregnenolone to 17-hydroxypregnenolone by upregulating the expression of 3β hydroxysteroid dehydrogenase enzyme (3β-HSD) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
17beta-estradiol | up-regulates
|
Corticotropin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268726 |
|
|
|
|
| pmid |
sentence |
| 24631756 |
ACTH and corticosterone responses to the same acute stress stimulus are higher in the pro-estrus phase of the cycle, when the serum concentrations of estrogen are the highest |Moreover, Kirschbaum et al. conducted a double blind study of 32 men, showing that 100 mcg of estradiol/day for two days was sufficient to produce statistically significant increases in ACTH |
|
| Publications: |
1 |
3.0
Corticotropin
- 
- 