Relation Results

Summary

Name Corticotropin
Full Name Corticotropin
Synonyms POMC, Corticotropin-lipotropin |
Primary ID P01189-PRO_0000024969
Links - -
Type protein
Relations 12
Function Stimulates the adrenal glands to release cortisol.

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Type: Score: Layout: SPV 
0.20.20.20.20.20.80.20.20.20.80.20.2CorticotropinMC2RMC1RMC3RMC4RCYP11A117beta-estradiolCRHR1MC5RPCSK1progesteronePCSK2HSD3B1

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Relations
Regulator
Mechanism
target
score ℹ
+ Corticotropinup-regulates activity img/direct-activation.png binding MC2R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268616 Cricetulus griseus
pmid sentence
Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate (cAMP).
Publications: 1 Organism: Cricetulus Griseus
Tissue: Adrenal Gland
+ Corticotropinup-regulates activity img/direct-activation.png binding MC1R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268701 Homo sapiens
pmid sentence
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ Corticotropinup-regulates activity img/direct-activation.png binding MC3R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268706 Homo sapiens
pmid sentence
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ Corticotropinup-regulates activity img/direct-activation.png binding MC4R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268711 Homo sapiens
pmid sentence
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ Corticotropinup-regulates quantity img/indirect-activation.png CYP11A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268719 Homo sapiens
pmid sentence
CTH signaling promotes the single steroidogenic rate limiting step, which is the conversion of cholesterol to pregnenolone by Cholesterol Side-Chain Cleavage Enzyme (P450scc), encoded in the CYP11A1 gene. This is conferred by a direct stimulating effect of ACTH on the promoter of CYP11A1 (Chung et al., 1997, Liu and Simpson, 1997, Hu et al., 2001). Further, it stimulates conversion of pregnenolone to 17-hydroxypregnenolone by upregulating the expression of 3β hydroxysteroid dehydrogenase enzyme (3β-HSD)
Publications: 1 Organism: Homo Sapiens
+ 17beta-estradiolup-regulates img/indirect-activation.png Corticotropin 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268726
pmid sentence
ACTH and corticosterone responses to the same acute stress stimulus are higher in the pro-estrus phase of the cycle, when the serum concentrations of estrogen are the highest |Moreover, Kirschbaum et al. conducted a double blind study of 32 men, showing that 100 mcg of estradiol/day for two days was sufficient to produce statistically significant increases in ACTH
Publications: 1
+ CRHR1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Corticotropin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268613 Homo sapiens
pmid sentence
CRH, as a principal mediator of endocrine stress response, activates the HPA axis (Hypothalamic–pituitary–adrenal axis) by binding to the CRHR1 in the anterior pituitary. This, through a cascade of reactions, increases the expression of proopiomelanocortin (POMC) gene and the subsequent release of POMC-derived peptides, adrenocorticotropic hormone (ACTH) and β-endorphin. ACTH, in turn, stimulates the secretion of glucocorticoids from adrenal cortex (Vale et al. 1981).
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
+ Corticotropinup-regulates activity img/direct-activation.png binding MC5R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268716 Homo sapiens
pmid sentence
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ PCSK1up-regulates quantity img/direct-activation.png cleavage Corticotropin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268724
pmid sentence
POMC is post-translationally cleaved by prohormone convertase enzymes 1 and 2 (PC1, PC2) into ACTH, an N-terminal glycopeptide
Publications: 1
+ progesteronedown-regulates img/indirect_inhibition.png Corticotropin 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268727
pmid sentence
ACTH and corticosterone responses to the same acute stress stimulus are higher in the pro-estrus phase of the cycle, when the serum concentrations of estrogen are the highest (Viau and Meaney, 1991). In the same study, it was shown that progesterone inhibits the sensitizing effects of estrogen on ACTH release during stress, as the ACTH levels and HPA output decreased with increasing amounts of progesterone in the estrous and diestrous phases.
Publications: 1
+ PCSK2up-regulates quantity img/direct-activation.png cleavage Corticotropin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268725
pmid sentence
POMC is post-translationally cleaved by prohormone convertase enzymes 1 and 2 (PC1, PC2) into ACTH, an N-terminal glycopeptide
Publications: 1
+ Corticotropinup-regulates quantity img/indirect-activation.png HSD3B1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268720 Homo sapiens
pmid sentence
CTH signaling promotes the single steroidogenic rate limiting step, which is the conversion of cholesterol to pregnenolone by Cholesterol Side-Chain Cleavage Enzyme (P450scc), encoded in the CYP11A1 gene. This is conferred by a direct stimulating effect of ACTH on the promoter of CYP11A1 (Chung et al., 1997, Liu and Simpson, 1997, Hu et al., 2001). Further, it stimulates conversion of pregnenolone to 17-hydroxypregnenolone by upregulating the expression of 3β hydroxysteroid dehydrogenase enzyme (3β-HSD)
Publications: 1 Organism: Homo Sapiens
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