3.0
Summary
| Name |  JUPView Modifications |
| Full Name | Junction plakoglobin |
| Synonyms | Catenin gamma, Desmoplakin III, Desmoplakin-3 | CTNNG, DP3 |
| Primary ID | P14923 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FYN | up-regulates activity 
phosphorylation
|
JUP | 0.535 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | FER | up-regulates activity
phosphorylation
|
JUP | 0.497 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | FYN | down-regulates activity 
phosphorylation
|
JUP | 0.535 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | FER | down-regulates activity
phosphorylation
|
JUP | 0.497 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | SRC | up-regulates activity
phosphorylation
|
JUP | 0.652 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | α-Catenin | up-regulates quantity
relocalization
|
JUP | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CTNNA3 | up-regulates quantity
relocalization
|
JUP | 0.5 |
| Publications: | 1 | Organism: | Homo Sapiens | |