| + |
GATA4 | up-regulates quantity by expression 
transcriptional regulation
|
α-Catenin |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265815 |
|
|
Homo sapiens |
Cardiac Muscle Fiber |
| pmid |
sentence |
| 21598020 |
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | up-regulates quantity
relocalization
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265818 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 21598020 |
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | down-regulates activity 
binding
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265820 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
α-Catenin |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | down-regulates activity
phosphorylation
|
α-Catenin |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265822 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 19941816 |
We demonstrate here that egfr activation results in disruption of the complex of beta-catenin and alpha-catenin, thereby abrogating the inhibitory effect of alpha-catenin on beta-catenin transactivation via ck2alpha-dependent phosphorylation of alpha-catenin at s641. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | up-regulates
|
F-actin_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN11 | down-regulates activity
dephosphorylation
|
α-Catenin |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265824 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16767162 |
Tyr148 of beta-catenin is an shp2 target dephosphorylation site. Together, these results suggest that beta-catenin plays a suppressor role in cell transformation and that shp2, by dephosphorylating beta-catenin, promotes mitogenic, cell survival and transformation signals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | up-regulates quantity
relocalization
|
CDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265817 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 21598020 |
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH11 | up-regulates activity
binding
|
α-Catenin |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265825 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10029089 |
Cadherin-11 is localized to a detergent-soluble pool and is associated with both alpha- and beta-catenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | up-regulates quantity
relocalization
|
JUP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265819 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 21598020 |
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH1 | up-regulates activity
binding
|
α-Catenin |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265821 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24336504 |
Additionally, the E-cadherin associated protein _-catenin regulates YAP directly by sequestering YAP/14-3-3 complexes in the cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
α-Catenin |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265816 |
|
|
Homo sapiens |
Cardiac Muscle Fiber |
| pmid |
sentence |
| 21598020 |
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
α-Catenin