Relation Results

Summary

Name CTNNA3
Full Name Catenin alpha-3
Synonyms Alpha T-catenin, Cadherin-associated protein |
Primary ID Q9UI47
Links - -
Type protein
Relations 5
Function May be involved in formation of stretch-resistant cell-cell adhesion complexes.

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Type: Score: Layout: SPV 
0.5650.2510.7520.4860.241CTNNA3CDH1GATA4CTNNB1JUPMEF2C

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Relations
Regulator
Mechanism
target
score ℹ
+ CTNNA3up-regulates quantity img/direct-activation.png relocalization CDH1 0.565
Identifier Residue Sequence Organism Cell Line
SIGNOR-265492 Homo sapiens Colonic Cancer Cell
pmid sentence
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14
Publications: 1 Organism: Homo Sapiens
+ GATA4up-regulates quantity by expression img/direct-activation.png transcriptional regulation CTNNA3 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-265490 Homo sapiens Cardiac Muscle Fiber
pmid sentence
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter
Publications: 1 Organism: Homo Sapiens
+ CTNNA3up-regulates quantity img/direct-activation.png relocalization CTNNB1 0.752
Identifier Residue Sequence Organism Cell Line
SIGNOR-265493 Homo sapiens Colonic Cancer Cell
pmid sentence
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14
Publications: 1 Organism: Homo Sapiens
+ CTNNA3up-regulates quantity img/direct-activation.png relocalization JUP 0.486
Identifier Residue Sequence Organism Cell Line
SIGNOR-265494 Homo sapiens Colonic Cancer Cell
pmid sentence
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14
Publications: 1 Organism: Homo Sapiens
+ MEF2Cup-regulates quantity by expression img/direct-activation.png transcriptional regulation CTNNA3 0.241
Identifier Residue Sequence Organism Cell Line
SIGNOR-265491 Homo sapiens Cardiac Muscle Fiber
pmid sentence
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter
Publications: 1 Organism: Homo Sapiens
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