| + |
LIF | up-regulates 
binding
|
LIFR |
0.75 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051226 |
Lif binds at low-affinity to lifr, the structure of which is closely related to that of gp130 (42). Lifr then becomes heterodimerized with gp130 to form the high-affinity and signaling-competent complex (43). Osm utilizes this type of heterodimer, i.e. the lifr/gp130 complex (43, 44). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Lif binds at low-affinity to lifr, the structure of which is closely related to that of gp130 (42). Lifr then becomes heterodimerized with gp130 to form the high-affinity and signaling-competent complex (43). Osm utilizes this type of heterodimer, i.e. the lifr/gp130 complex (43, 44). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204847 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
LIF | up-regulates
binding
|
IL6ST |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48108 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors.Some Of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates quantity by expression 
transcriptional regulation
|
LIF |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251941 |
|
|
Homo sapiens |
GBM-8401 Cell |
| pmid |
sentence |
| 20383200 |
Nodal induced LIF and Cripto-1 expressions through Smad2 signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LIF | up-regulates quantity by expression
transcriptional regulation
|
MYH7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251959 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10212267 |
Increase of protein synthesis rate and β-MHC gene expression in cardiac myocytes by ET-1 and LIF. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
LIF
- 
- 