Summary

Name LIF
Full Name Leukemia inhibitory factor
Synonyms LIF, Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor, MLPLI | HILDA
Primary ID P15018
Links - -
Type protein
Relations 6
Function LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LIF 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH7 0.11
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding IL6ST 0.92
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LIFR 0.96
Publications: 3 Organism: Homo Sapiens