| + |
ATM | up-regulates quantity by expression 
transcriptional regulation
|
PVR |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253927 |
|
|
Homo sapiens |
Natural Killer Cell |
| pmid |
sentence |
| 21406724 |
The up-regulation of PVR expression involves DNA-damage response (DDR)-dependent pathways, because we found that pharmacologic inhibition of ATM and ATR kinases reduced PVR expression and that PVR was almost exclusively induced on cells expressing the DDR marker γH2AX. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PVR | up-regulates activity 
binding
|
TIGIT |
0.867 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261425 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30591568 |
Poliovirus receptor (PVR/CD155) is a ligand of the paired NK receptors, DNAM-1 (activating) and TIGIT (inhibiting). NK cells can kill cancer cells expressing PVR via the DNAM-1-mediated activating signaling (11,12). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARCHF9 | down-regulates quantity by destabilization 
ubiquitination
|
PVR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271530 |
|
|
Homo sapiens |
B-lymphocyte Cell Line |
| pmid |
sentence |
| 19457934 |
MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino acids in cell culture (SILAC) to determine the differential expression of plasma membrane proteins in a MARCH9-expressing B cell line. This combined approach identified 13 potential new MARCH9 targets. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PVR | up-regulates activity
binding
|
CD226 |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261424 |
|
|
Homo sapiens |
Natural Killer Cell |
| pmid |
sentence |
| 30591568 |
We focused on receptor-ligand interactions between CAFs and NK cell and found that cell-surface poliovirus receptor (PVR/CD155), a ligand of activating NK receptor DNAM-1, was downregulated in the CAFs compared with NEFs. |Poliovirus receptor (PVR/CD155) is a ligand of the paired NK receptors, DNAM-1 (activating) and TIGIT (inhibiting). NK cells can kill cancer cells expressing PVR via the DNAM-1-mediated activating signaling (11,12). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PVR
- 
- 