| + |
TIMP2 | down-regulates 
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252273 |
|
|
|
|
| pmid |
sentence |
| 17326328 |
There are many naturally occurring proteins that can inhibit angiogenesis, including angiostatin, endostatin, interferon, platelet factor 4, thorombospondin, prolactin 16 kd fragment, and tissue inhibitor of metalloproteinase-1, -2, and -3 |
|
| Publications: |
1 |
| + |
TIMP2 | up-regulates quantity 
binding
|
LRP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265254 |
|
|
Rattus norvegicus |
Yolk Sac Cancer Cell |
| pmid |
sentence |
| 28659595 |
We show that megalin/LRP-2 acts as an endocytic receptor for proMMP-2:TIMP-2 complex. We found that RAP, an antagonist of the LDL receptor family18, competed with binding of proMMP-2:TIMP-2 complex onto rat BN16 epithelial cells. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
DNMT3A | down-regulates quantity by repression
transcriptional regulation
|
TIMP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255807 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19786833 |
Based on one of these publications, we here showed that the interaction of Dnmt3a with c-myc promote the specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a, CCND1 and TIMP2 genes. Acellular experiments corroborated and complemented these results by revealing that the specificity of consensus sequence for DNA methylation of Dnmt3a is increased in presence of c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | down-regulates quantity
|
TIMP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255069 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19351864 |
Suppressing PTTG expression by siRNA decreased cell motility in both PTTG-HA/EC9706 and KYSE150 cells. By using mass spectrometric analysis, we identified that PTTG up-regulated S100A4 and galectin-1 secretion and down-regulated tissue inhibitor of metalloproteinase-2 secretion to the culture media. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TIMP2
- 
- 