Summary

Name TIMP2
Full Name Metalloproteinase inhibitor 2
Synonyms CSC-21K, Tissue inhibitor of metalloproteinases 2, TIMP-2 |
Primary ID P16035
Links - -
Type protein
Relations 4
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

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Relations

Regulator Mechanism target score ℹ
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TIMP2 0.2
Publications: 1 Organism: Homo Sapiens
+ TIMP2down-regulates img/indirect_inhibition.png Angiogenesis 0.7
Publications: 1
+ TIMP2up-regulates quantity img/direct-activation.png binding LRP2 0.2
Publications: 1 Organism: Rattus Norvegicus
+ PTTG1down-regulates quantity img/indirect_inhibition.png TIMP2 0.2
Publications: 1 Organism: Homo Sapiens