| + |
MAPK1 | up-regulates 
phosphorylation
|
PTTG1 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79515 |
Ser165 |
LFQLGPPsPVKMPSP |
Homo sapiens |
|
| pmid |
sentence |
| 10906323 |
Pttg is phosphorylated in vitro on ser(162) by map kinase and this phosphorylation site plays an essential role in pttg transactivation function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
PTTG1 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74619 |
Ser165 |
LFQLGPPsPVKMPSP |
Homo sapiens |
|
| pmid |
sentence |
| 10656688 |
Hpttg is phosphorylated by cdc2 at ser165 these results suggest that hpttg is induced by, and may have a role in, regulatory pathways involved in the control of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
PTTG1 |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79519 |
Ser165 |
LFQLGPPsPVKMPSP |
Homo sapiens |
|
| pmid |
sentence |
| 10906323 |
Pttg is phosphorylated in vitro on ser(162) by map kinase and this phosphorylation site plays an essential role in pttg transactivation function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
PTTG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276345 |
Ser183 |
SNLLQSPsSILSTLD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21757741 |
Here, we demonstrate that glycogen synthase kinase-3β (GSK3β) phosphorylates securin to promote its proteolysis via SCF(βTrCP) E3 ubiquitin ligase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276344 |
Ser184 |
NLLQSPSsILSTLDV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21757741 |
Here, we demonstrate that glycogen synthase kinase-3β (GSK3β) phosphorylates securin to promote its proteolysis via SCF(βTrCP) E3 ubiquitin ligase. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CAMK2A | down-regulates quantity by destabilization
phosphorylation
|
PTTG1 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276382 |
Ser31 |
LKLGSGPsIKALDGR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276381 |
Ser87 |
PLKQKQPsFSAKKMT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276383 |
Ser89 |
KQKQPSFsAKKMTEK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276377 |
Thr66 |
ATRKALGtVNRATEK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | up-regulates quantity by stabilization
dephosphorylation
|
PTTG1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276379 |
Ser31 |
LKLGSGPsIKALDGR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276378 |
Ser87 |
PLKQKQPsFSAKKMT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276380 |
Ser89 |
KQKQPSFsAKKMTEK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276376 |
Thr66 |
ATRKALGtVNRATEK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24781523 |
CaMKII phosphorylates securin at PP2A substrate site(s).Securin is destabilized by phosphorylation and stabilized by PP2A-dependent dephosphorylation on separase |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
UBE4B | down-regulates quantity by destabilization
polyubiquitination
|
PTTG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15611659 |
We further demonstrate that Ufd2 directly and efficiently ubiquitylates securin in vitro and is required for securin polyubiquitylation in vivo. This is the first description of a physiologic substrate for Ufd2, establishing this E4 enzyme as an important regulator of chromosome condensation and separation during mitosis in human cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | down-regulates activity
binding
|
ESPL1 |
0.943 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15737063 |
Prior to anaphase, separase is kept inactive by its inhibitor securin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | up-regulates activity 
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256535 |
|
|
Mus musculus |
MCF-7 Cell |
| pmid |
sentence |
| 22002306 |
Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Gbeta | up-regulates
phosphorylation
|
PTTG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270038 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10906323 |
Pttg is phosphorylated in vitro on ser(162) by map kinase and this phosphorylation site plays an essential role in pttg transactivation function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | up-regulates quantity by expression
transcriptional regulation
|
LGALS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255068 |
|
|
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell Line |
| pmid |
sentence |
| 19351864 |
PTTG induced S100A4 and galectin-1 mRNA and protein expression as assessed by Western blot and reverse transcription-PCR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | up-regulates quantity by expression
transcriptional regulation
|
S100A4 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255070 |
|
|
Homo sapiens |
Lec15.1 CHO Cell |
| pmid |
sentence |
| 19351864 |
PTTG induced S100A4 and galectin-1 mRNA and protein expression as assessed by Western blot and reverse transcription-PCR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
PTTG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10906323 |
Pttg is phosphorylated in vitro on ser(162) by map kinase and this phosphorylation site plays an essential role in pttg transactivation function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | down-regulates quantity 
|
TIMP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255069 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19351864 |
Suppressing PTTG expression by siRNA decreased cell motility in both PTTG-HA/EC9706 and KYSE150 cells. By using mass spectrometric analysis, we identified that PTTG up-regulated S100A4 and galectin-1 secretion and down-regulated tissue inhibitor of metalloproteinase-2 secretion to the culture media. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC-c | down-regulates quantity by destabilization
ubiquitination
|
PTTG1 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265049 |
|
|
|
|
| pmid |
sentence |
| 21596315 |
Complexed with the activator proteins CDC20 or CDH1 (Fang et al., 1998, Visintin et al., 1997), the APC/C recognizes, ubiquitinates, and targets for proteasomal degradation a multitude of cell cycle regulators containing KEN or D box degrons, including securin, cyclin A, and cyclin B. |
|
| Publications: |
1 |
3.0
PTTG1
- 
- 