Relation Results

Summary

Name LRP2
Full Name Low-density lipoprotein receptor-related protein 2
Synonyms LRP-2, Glycoprotein 330, gp330, Megalin |
Primary ID P98164
Links - -
Type protein
Relations 4
Function Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates ...
View More

Viewer

Type: Score: Layout: SPV 
0.3450.20.4880.566MMP2LRP2TIMP2PTCH1CLU

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ MMP2up-regulates quantity img/direct-activation.png binding LRP2 0.345
Identifier Residue Sequence Organism Cell Line
SIGNOR-265255 Rattus norvegicus
pmid sentence
We show that megalin/LRP-2 acts as an endocytic receptor for proMMP-2:TIMP-2 complex. We found that RAP, an antagonist of the LDL receptor family18, competed with binding of proMMP-2:TIMP-2 complex onto rat BN16 epithelial cells.
Publications: 1 Organism: Rattus Norvegicus
+ TIMP2up-regulates quantity img/direct-activation.png binding LRP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265254 Rattus norvegicus Yolk Sac Cancer Cell
pmid sentence
We show that megalin/LRP-2 acts as an endocytic receptor for proMMP-2:TIMP-2 complex. We found that RAP, an antagonist of the LDL receptor family18, competed with binding of proMMP-2:TIMP-2 complex onto rat BN16 epithelial cells.
Publications: 1 Organism: Rattus Norvegicus
+ LRP2up-regulates quantity img/direct-activation.png binding PTCH1 0.488
Identifier Residue Sequence Organism Cell Line
SIGNOR-265257 Homo sapiens
pmid sentence
LRP2 Promotes SHH Activity in Neurogenic Niches of the Developing and Adult Brain. In the RDVM, LRP2 forms a co-receptor complex with PTCH1 facilitating SHH binding and internalization of SHH/PTCH1 complexes, a prerequisite for pathway activation (Fig. 3B).
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ CLUup-regulates quantity img/direct-activation.png binding LRP2 0.566
Identifier Residue Sequence Organism Cell Line
SIGNOR-265256 Mus musculus
pmid sentence
Our results demonstrate that circulating ApoJ is retained in muscle via LRP2 and that LRP2 signaling could play a role in the maintenance of ApoJ homeostasis in circulation, at least in part.
Publications: 1 Organism: Mus Musculus
a simple tooltip