Summary

Name SELP
Full Name P-selectin
Synonyms CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, Platelet activation dependent granule-external membrane protein, PADGEM | GMRP, GRMP
Primary ID P16109
Links - -
Type protein
Relations 4
Function Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding SELP 0.925
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates activity img/direct-activation.png binding GPIb-IX-V complex 0.423
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SELP 0.305
Publications: 1 Organism: Homo Sapiens