+ |
SELPLG | up-regulates
binding
|
SELP |
0.925 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-47625 |
|
|
Homo sapiens |
Neutrophil, Breast Cancer Cell, Lung Cancer Cell |
pmid |
sentence |
9129046 |
The major ligand for p-selectin on leukocytes is p-selectin glycoprotein ligand-1 (PSGL-1) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255038 |
|
|
Homo sapiens |
Neutrophil |
pmid |
sentence |
23994464 |
This steady-state rolling is primarily mediated by the interaction of endothelial P-selectins with their neutrophil glycoprotein counterreceptors, primarily PSGL-1. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Tissue: |
Ovary |
+ |
SELP | up-regulates activity
binding
|
GPIb-IX-V complex |
0.419 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261860 |
|
|
Homo sapiens |
Blood Platelet |
pmid |
sentence |
25297919 |
Besides VWF as a main ligand, GPIbα also binds multiple ligands such as thrombospondin, Factor XII, Factor XI, thrombin, High Molecular Weight kininogen, P-selectin and Mac-1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NBEAL2 | up-regulates
|
SELP |
0.302 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261885 |
|
|
Homo sapiens |
Blood Platelet |
pmid |
sentence |
28082341 |
Recent in vitro megakaryopoiesis studies using HSCs from GPS patients with NBEAL2 mutations showed normal MK differentiation with defective proplatelet formation and reduced α-granule proteins such as von Willebrand factor (VWF), thrombospondin and P-selectin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |