| + |
CHAF1B | down-regulates quantity by repression 
transcriptional regulation
|
MGMT |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254570 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15657354 |
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255437 |
|
|
Homo sapiens |
Glioma Cell Line |
| pmid |
sentence |
| 17564708 |
we observed that IFN-beta sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to attenuation of MGMT expression via induction of TP53. In this context, IFN-beta inactivates MGMT via p53 gene induction and enhances the therapeutic efficacy to TMZ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHAF1A | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254569 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15657354 |
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254035 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15657354 |
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MBD1 | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254036 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15657354 |
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNB1 | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255438 |
|
|
Homo sapiens |
Glioma Cell Line |
| pmid |
sentence |
| 17564708 |
we observed that IFN-beta sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to attenuation of MGMT expression via induction of TP53. In this context, IFN-beta inactivates MGMT via p53 gene induction and enhances the therapeutic efficacy to TMZ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MGMT
- 
- 