Relation Results

Summary

Name MGMT
Full Name Methylated-DNA--protein-cysteine methyltransferase
Synonyms 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase |
Primary ID P16455
Links - -
Type protein
Relations 6
Function Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methyla ...
View More

Viewer

Type: Score: Layout: SPV 
0.2980.4860.310.20.2530.363CHAF1BMGMTTP53MECP2CHAF1AMBD1IFNB1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ CHAF1Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.298
Identifier Residue Sequence Organism Cell Line
SIGNOR-254570 Homo sapiens HeLa Cell
pmid sentence
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT.
Publications: 1 Organism: Homo Sapiens
+ TP53down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.486
Identifier Residue Sequence Organism Cell Line
SIGNOR-255437 Homo sapiens Glioma Cell Line
pmid sentence
we observed that IFN-beta sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to attenuation of MGMT expression via induction of TP53. In this context, IFN-beta inactivates MGMT via p53 gene induction and enhances the therapeutic efficacy to TMZ.
Publications: 1 Organism: Homo Sapiens
+ MECP2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.31
Identifier Residue Sequence Organism Cell Line
SIGNOR-254035 Homo sapiens HeLa Cell
pmid sentence
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT.
Publications: 1 Organism: Homo Sapiens
+ CHAF1Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254569 Homo sapiens HeLa Cell
pmid sentence
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT.
Publications: 1 Organism: Homo Sapiens
+ MBD1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.253
Identifier Residue Sequence Organism Cell Line
SIGNOR-254036 Homo sapiens HeLa Cell
pmid sentence
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT.
Publications: 1 Organism: Homo Sapiens
+ IFNB1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.363
Identifier Residue Sequence Organism Cell Line
SIGNOR-255438 Homo sapiens Glioma Cell Line
pmid sentence
we observed that IFN-beta sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to attenuation of MGMT expression via induction of TP53. In this context, IFN-beta inactivates MGMT via p53 gene induction and enhances the therapeutic efficacy to TMZ.
Publications: 1 Organism: Homo Sapiens
a simple tooltip