Summary

Name GOT1
Full Name Aspartate aminotransferase, cytoplasmic
Synonyms cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A |
Primary ID P17174
Links - -
Type protein
Relations 9
Pathways Aspartate and asparagine metabolism, Glutamine metabolism
Function Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification 2-oxoglutarate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GOT1 0.2
Publications: 1
+ up-regulates quantity img/direct-activation.png chemical modification oxaloacetate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ up-regulates quantity img/direct-activation.png chemical modification L-aspartate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ down-regulates quantity img/direct_inhibition.png chemical modification oxaloacetate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ down-regulates quantity img/direct_inhibition.png chemical modification L-aspartate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ down-regulates quantity img/direct_inhibition.png chemical modification 2-oxoglutarate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism
+ down-regulates quantity img/direct_inhibition.png chemical modification L-glutamate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism
+ up-regulates quantity img/direct-activation.png chemical modification L-glutamate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism