| + |
HOXB8 | up-regulates activity 
binding
|
PBX3 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223149 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 11571641 |
the ability of HoxB8 to heterodimerizes with endogenous Pbx proteins on DNA alters gene transcription in a manner that prevents progression through an intrinsic genetic differentiation program. In conjunction with Pbx, HoxB8 could alter transcription of Pbx target genes by direct or indirect mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB8 | down-regulates quantity by repression 
transcriptional regulation
|
ACTA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261641 |
|
|
Rattus norvegicus |
A10 Cell |
| pmid |
sentence |
| 15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
HOXB8 | down-regulates quantity by repression
transcriptional regulation
|
MYLK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261640 |
|
|
Rattus norvegicus |
A10 Cell |
| pmid |
sentence |
| 15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
HOXB8 | down-regulates quantity by repression
transcriptional regulation
|
TAGLN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261642 |
|
|
Rattus norvegicus |
A10 Cell |
| pmid |
sentence |
| 15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
HOXB8 | up-regulates activity
binding
|
PBX1 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223153 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 11571641 |
the ability of HoxB8 to heterodimerizes with endogenous Pbx proteins on DNA alters gene transcription in a manner that prevents progression through an intrinsic genetic differentiation program. In conjunction with Pbx, HoxB8 could alter transcription of Pbx target genes by direct or indirect mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HOXB8
- 
- 