| + |
TGFB1 | up-regulates quantity by expression 
transcriptional regulation
|
ACTA2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11988769 |
A TGF-β1 response element that has a sequence different to that known for Smad binding has been identified in the α- SM actin promoter and seems to be essential for expression of α-SM actin in both SM cells 72 and myofibroblasts73 . How TGF-β1 activates expression of α-SM actin through this TGF-β1 control element is, as yet, unknown |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroblast |
| + |
SRF | up-regulates quantity by expression 
transcriptional regulation
|
ACTA2 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15269336 |
The primary goal of the present study was to directly assess the role of the degeneracy of sm ?-Actin cargs in the regulation of smc-selective gene expression in vivo. in addition, our present studies address the possible role of this carg degeneracy, and the smc-selective srf coactivator myocardin, in regulating differential expression of carg-dependent smc genes and growth regulatory genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ACTA2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251923 |
|
|
Homo sapiens |
Lung Fibroblast |
| pmid |
sentence |
| 20846954 |
We used diploid human lung fibroblasts (WI38 cells) induced by TGFβ to differentiate into myofibroblast-like cells. In order to characterize this system, we first studied the expression of the myofibroblast marker genes ACTA2 (coding for smooth muscle α-actin; SMA), COL4A1 (encoding collagen type IV α1) and SM22A (coding for smooth muscle protein 22-α). As shown in Figure 1A and B, TGFβ induced the expression all three genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACTA2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11988769 |
It has subsequently been shown that most myofibroblasts express α-SM actin (the actin isoform typically found in vascular SM cells)13,14 and that the expression of α-SM actin and collagen type I in these cells is coordinately regulated by transforming growth factor β1 (TGF-β1)15. All these observations indicate that the myofibroblast has a role in the synthesis of ECM and in force generation, which results in ECM reorganization and wound contraction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB8 | down-regulates quantity by repression 
transcriptional regulation
|
ACTA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261641 |
|
|
Rattus norvegicus |
A10 Cell |
| pmid |
sentence |
| 15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Activated PSC | up-regulates quantity
|
ACTA2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28232471 |
Upon activa- tion, PSCs express the myofibroblast protein α-smooth mus- cle actin (αSMA, gene name Acta2) and secrete factors that stimulate tumor growth, cell survival, and metastasis. As a result of the selective high expression of αSMA, we refer to these periglandular FAP+ αSMAhigh fibroblasts as myofibroblastic CAFs (myCAFs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Pancreas |
3.0
ACTA2
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