+ |
PRKCD | down-regulates activity
phosphorylation
|
TAGLN |
0.332 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249061 |
Ser181 |
VIGLQMGsNRGASQA |
in vitro |
|
pmid |
sentence |
11053353 |
Of the three consensus protein kinase C or casein kinase II phosphorylation sites in SM22, only Ser-181 was readily phosphorylated by protein kinase C in vitro, and such phosphorylation greatly decreased actin binding. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
HOXB8 | down-regulates quantity by repression
transcriptional regulation
|
TAGLN |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261642 |
|
|
Rattus norvegicus |
A10 Cell |
pmid |
sentence |
15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
TAGLN |
0.345 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251924 |
|
|
Homo sapiens |
|
pmid |
sentence |
20846954 |
We used diploid human lung fibroblasts (WI38 cells) induced by TGFβ to differentiate into myofibroblast-like cells. In order to characterize this system, we first studied the expression of the myofibroblast marker genes ACTA2 (coding for smooth muscle α-actin; SMA), COL4A1 (encoding collagen type IV α1) and SM22A (coding for smooth muscle protein 22-α). As shown in Figure 1A and B, TGFβ induced the expression all three genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SRF | up-regulates quantity by expression
transcriptional regulation
|
TAGLN |
0.423 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-174393 |
|
|
Homo sapiens |
|
pmid |
sentence |
21673106 |
The contractile phenotype of smooth muscle (sm) cells is controlled by serum response factor (srf), which drives the expression of sm-specific genes including sm alpha-actin, sm22, and others. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |