Insulin Receptor

Pathway ID: SIGNOR-INSRView in NDEx

Description: In physiological conditions, insulin controls critical energy functions such as glucose and lipid metabolism. Insulin binds and activates the insulin receptor tyrosine kinase (IR), which phosphorylates and recruits different substrate adaptors. Tyrosine phosphorylated substrates, in turn, act as scaffolds for numerous partners, initiating a signaling cascade that involve via PI3K/Akt and Ras/MAP kinase pathways.

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

35 Seed Entities

Organism:
Name Primary ID
EIF4EBP1 Q13541
MTOR P42345
HRAS P01112
RHEB Q15382
PTPN1 P18031
PTEN P60484
SLC2A2 P11168
SOS1 Q07889
GSK3B P49841
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
Cell Growth SIGNOR-PH33
JUN P05412
SGK1 O00141
mTORC1 SIGNOR-C3
GYS1 P13807
Protein Synthesis SIGNOR-PH29
Lipogenesis SIGNOR-PH30
glycogen synthesis SIGNOR-PH39
TSC1/TSC2 SIGNOR-C101
EIF4E P06730
INSR P06213
RPS6KB1 P23443
GRB2 P62993
MEK1/2 SIGNOR-PF25
INS P01308
IRS1 P35568
RAF1 P04049
PDX1 P52945
FOXO3 O43524
ERK1/2 SIGNOR-PF1
SREBF1 P36956
PDPK1 O15530
PIK3CB P42338
SLC2A4 P14672
AKT SIGNOR-PF24