| + |
CLK1 | up-regulates activity 
phosphorylation
|
RBM17 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262705 |
Ser202 |
EEDSRPRsQSSKAAI |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. Clk1 promotes SPF45-induced exon 6 exclusion |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262706 |
Ser204 |
DSRPRSQsSKAAIPP |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262707 |
Ser222 |
EEQDRPRsPTGPSNS |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262708 |
Ser266 |
QGLSTALsVEKTSKR |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262709 |
Ser288 |
DATEKDAsKKSDSNP |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262710 |
Ser291 |
EKDASKKsDSNPLTE |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262711 |
Ser48 |
KSQRTKQsTVLAPVI |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262712 |
Ser62 |
IDLKRGGsSDDRQIV |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 23519612 |
In this work, we show that Cdc2-like kinase 1 (Clk1) phosphorylates SPF45 on eight serine residues. |
|
| Publications: |
8 |
Organism: |
Chlorocebus Aethiops |
| + |
CLK1 | up-regulates activity
phosphorylation
|
PTPN1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250773 |
Ser242 |
MDKRKDPsSVDIKKV |
in vitro |
|
| pmid |
sentence |
| 10480872 |
The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. | although CLK1 and CLK2 directly phosphorylate PTP-1B on both Ser50 and Ser242/Ser243, the preferred CLK phosphorylation site is Ser50, as it is preferentially phosphorylated at an approximate ratio of 9:1 over the Ser242/Ser243 site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250774 |
Ser243 |
DKRKDPSsVDIKKVL |
in vitro |
|
| pmid |
sentence |
| 10480872 |
The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. | although CLK1 and CLK2 directly phosphorylate PTP-1B on both Ser50 and Ser242/Ser243, the preferred CLK phosphorylation site is Ser50, as it is preferentially phosphorylated at an approximate ratio of 9:1 over the Ser242/Ser243 site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70563 |
Ser50 |
RNRYRDVsPFDHSRI |
Homo sapiens |
|
| pmid |
sentence |
| 10480872 |
The clk family kinases, clk1 and clk2, phosphorylate and activate the tyrosine phosphatase, ptp-1b.|Phosphorylation of PTP-1B at Ser(50) by CLK1 or CLK2 is responsible for its enzymatic activation. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens |
| + |
CLK1 | down-regulates 
phosphorylation
|
ABL1 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181031 |
Thr735 |
DTEWRSVtLPRDLQS |
Homo sapiens |
|
| pmid |
sentence |
| 18794806 |
Here, we identify clk1, clk4, mst1, mst2 and ttk (also known as mps1) as novel thr735 kinases in vitro / phosphorylation of thr735 in c-abl is critical for binding to 14-3-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLK1 | up-regulates activity
phosphorylation
|
SRSF1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273857 |
|
|
in vitro |
|
| pmid |
sentence |
| 8617202 |
In vitro, Clk/Sty efficiently phosphorylated the SR family member ASF/SF2 on serine residues located within its serine/arginine-rich region (the RS domain). Overexpression of the active Clk/Sty kinase caused a redistribution of SR proteins within the nucleus. These results suggest that Clk/Sty kinase directly regulates the activity and compartmentalization of SR splicing factors. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
CLK1
- 
- 