| + |
PRKCD | up-regulates activity 
phosphorylation
|
PTPRA |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249113 |
Ser189 |
QAGSHSNsFRLSNGR |
Homo sapiens |
A-431 Cell |
| pmid |
sentence |
| 11676480 |
In this process, PTPalpha Ser-180 and Ser-204 phosphorylation is critical for the induction of phosphatase activity, which is required for dephosphorylation of pp60(c-src). Taken together, we demonstrate the physical and functional association between PI 3-kinase, PKCdelta and PTPalpha in a signaling complex that mediates the antitumor activity of the somatostatin analogue TT-232. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249114 |
Ser213 |
PLLARSPsTNRKYPP |
Homo sapiens |
|
| pmid |
sentence |
| 11676480 |
In this process, PTPalpha Ser-180 and Ser-204 phosphorylation is critical for the induction of phosphatase activity, which is required for dephosphorylation of pp60(c-src). Taken together, we demonstrate the physical and functional association between PI 3-kinase, PKCdelta and PTPalpha in a signaling complex that mediates the antitumor activity of the somatostatin analogue TT-232. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTPRA | down-regulates activity 
dephosphorylation
|
LYN |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248436 |
Tyr397 |
RVIEDNEyTAREGAK |
Rattus norvegicus |
|
| pmid |
sentence |
| 15537644 |
We found that PTPα and SHP-1 both dephosphorylate Lyn exclusively at Tyr-397|Lyn expressed in CHO cells has a substantially higher specific activity than Lyn in RBL cells because of high levels of phosphorylation at its active site Tyr-397 (Fig. 1). Enhanced Lyn kinase activity in the CHO cells leads to spontaneous phosphorylation of multiple cellular proteins, including FcϵRI |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PTPRA | up-regulates activity
dephosphorylation
|
SRC |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248437 |
Tyr530 |
FTSTEPQyQPGENL |
Homo sapiens |
|
| pmid |
sentence |
| 17974954 |
Several protein tyrosine phosphatases are capable of activating Src by dephosphorylating Y530 (reviewed in ref. 9). These include PTP-α, PTP-λ, SHP-1, SHP-2, and PTP1B |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248438 |
Tyr530 |
FTSTEPQyQPGENL |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10698938 |
Protein tyrosine phosphatase alpha (PTPalpha) is believed to dephosphorylate physiologically the Src proto-oncogene at phosphotyrosine (pTyr)527, a critical negative-regulatory residue. It thereby activates Src, and PTPalpha overexpression neoplastically transforms NIH 3T3 cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
PTPRA | up-regulates
dephosphorylation
|
SRC |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-32014 |
Tyr530 |
FTSTEPQyQPGENL |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 7691597 |
Endogenous pp60c-src kinase activity is enhanced in the rptp alpha-transfected cells, which may be due to direct dephosphorylation of the regulatory tyr residue at position 527 in pp60c-src by rptp alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRA | up-regulates
dephosphorylation
|
FYN |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154796 |
Tyr531 |
FTATEPQyQPGENL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17507376 |
Ptpalpha is a more widely expressed transmembrane ptp that has been shown to regulate the src family kinases, src and fyn, and is also present in t cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRA | up-regulates activity
dephosphorylation
|
FYN |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248435 |
Tyr531 |
FTATEPQyQPGENL |
Mus musculus |
Brain Cell Line |
| pmid |
sentence |
| 9535845 |
In a coexpression system, PTPalpha effected a dose-dependent tyrosine dephosphorylation and activation of p59(fyn), where maximal dephosphorylation correlated with a 5-fold increase in kinase activity.|the increased p59fyn catalytic activity and SH2 availability for binding are consistent with a PTPα-mediated dephosphorylation of the C-terminal Tyr-531 of p59fyn. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SRC | up-regulates activity
phosphorylation
|
PTPRA |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111306 |
Tyr798 |
YIDAFSDyANFK |
Homo sapiens |
|
| pmid |
sentence |
| 7518772 |
Transient overexpression of c-src together with rptp alpha in human embryonic kidney 293 cells increased phosphorylation of tyr789, suggesting that c-src may phosphorylate rptp alpha in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRA | down-regulates activity
dephosphorylation
|
PTPRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248439 |
Tyr798 |
YIDAFSDyANFK |
Homo sapiens |
|
| pmid |
sentence |
| 7518772 |
Transient overexpression of c-Src together with RPTP alpha in human embryonic kidney 293 cells increased phosphorylation of Tyr789, suggesting that c-Src may phosphorylate RPTP alpha in vivo. RPTP alpha had autodephosphorylation activity in vitro. When expressed in 293 cells the level of Tyr789 phosphorylation was higher in a non-functional mutant of RPTP alpha than in wild type RPTP alpha, indicating that RPTP alpha may have autodephosphorylation activity in vivo as well.|We show that RPTP alpha, but not a mutant of RPTP alpha with a Tyr-->Phe mutation at position 789, bound to GRB2 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRA | down-regulates activity
dephosphorylation
|
VPS33B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18474358 |
Here, we report that VPS33B, a host protein involved in vesicle trafficking, is dephosphorylated by PtpA leading to a block of phagosome maturation by M. tuberculosis.|These data suggest that M. tuberculosis PtpA inhibits phagosome maturation.To assess the role of VPS33B in phagosome maturation, we attenuated the expression of endogenous VPS33B expression in THP-1 cells using a siRNA based approach. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRA | down-regulates
dephosphorylation
|
KCNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148301 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16870705 |
Ptpalpha inhibits kv channels more strongly than ptpepsilon;this correlates with constitutive association of ptpalpha with kv2.1, driven by membranal localization of ptpalpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARCHF9 | down-regulates quantity by destabilization
ubiquitination
|
PTPRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271540 |
|
|
Homo sapiens |
B-lymphocyte Cell Line |
| pmid |
sentence |
| 19457934 |
MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino acids in cell culture (SILAC) to determine the differential expression of plasma membrane proteins in a MARCH9-expressing B cell line. This combined approach identified 13 potential new MARCH9 targets. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PTPRA
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