Relation Results

Summary

Name PDE6G
Full Name Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Synonyms GMP-PDE gamma | PDEG
Primary ID P18545
Links - -
Type protein
Relations 4
Function Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototran ...
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Type: Score: Layout: SPV 
0.20.7630.866GRK2PDE6GGNAT1PDE6A

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ GRK2up-regulates activity img/direct-activation.png phosphorylation PDE6G 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251459 Thr62 PGMEGLGtDITVICP Homo sapiens HEK-293 Cell
pmid sentence
Rod PDEγ is predominantly phosphorylated by GRK2 at the Thr-62. GRK2 is required for the stimulatory effect of rod PDEγ on both the EGF- and thrombin-dependent activation of p42/p44 MAPK
Identifier Residue Sequence Organism Cell Line
SIGNOR-247823 Thr62 PGMEGLGtDITVICP Homo sapiens HEK-293 Cell
pmid sentence
Mutation of Thr-62 (to Ala) in PDEgamma produced a GRK2 phosphorylation-resistant mutant that was less effective in associating with GRK2 in response to epidermal growth factor and did not potentiate the stimulation of p42/p44 mitogen-activated protein kinase by this growth factor.
Publications: 2 Organism: Homo Sapiens
+ GNAT1down-regulates activity img/direct_inhibition.png binding PDE6G 0.763
Identifier Residue Sequence Organism Cell Line
SIGNOR-260008 Mus musculus
pmid sentence
In the dark, PDE6 activity is suppressed by its inhibitory γ-subunit (Pγ). Rhodopsin-catalyzed activation of the G protein, transducin, relieves this inhibition and enhances PDE6 catalysis.
Publications: 1 Organism: Mus Musculus
+ PDE6Gdown-regulates activity img/direct_inhibition.png binding PDE6A 0.866
Identifier Residue Sequence Organism Cell Line
SIGNOR-260010 Homo sapiens
pmid sentence
Both PDE6C-A and PDE6C-B were potently and similarly inhibited by both Pγ subunits, with Ki values ranging from 33 to 46 pm (Fig. 5). The inhibition analysis revealed no significant differences between PDE6C-A and PDE6C-B
Publications: 1 Organism: Homo Sapiens
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