Relation Results

Summary

Name	GRK2 View Modifications
Full Name	Beta-adrenergic receptor kinase 1
Synonyms	Beta-ARK-1, G-protein coupled receptor kinase 2 \| BARK, BARK1, GRK2
Primary ID	P25098
Links	- -
Type	protein
Relations	73
Pathways	Oxytocin signaling
Function	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927).

Viewer

Search Tools

Refine search:

by mechanism

by effect

by organism:

by tissue:

by cell-line

▶Modifications Tables

GRK2 as Modifier

Residue

Sequence

Target

Effect

Modification

Ser102

KDEKKEEsEESDDDM

activation

phosphorylation

Ser105

KKEESEEsDDDMGFG

activation

phosphorylation

Ser108

S-->L

inhibition

phosphorylation

Ser1104

PRAEAEDsFL

inhibition

phosphorylation

Ser124

EVAEEAQsGGD

inhibition

phosphorylation

Ser1278

EPGFREVsFYYSEEN

inhibition

phosphorylation

Ser129

NEAYEMPsEEGYQDY

inhibition

phosphorylation

Ser18

LKKLSEDsLTKQPEE

activation

phosphorylation

Ser205

EKVSRTFsKLDYSGI

inhibition

phosphorylation

Ser205

LCDFNPKsSKQCKDV

unknown

phosphorylation

Ser239

AQQRPRDsEVEMMAQ

inhibition

phosphorylation

Ser311

DALDLEEsSSSDHAE

inhibition

phosphorylation

Ser312

ALDLEESsSSDHAER

inhibition

phosphorylation

Ser313

LDLEESSsSDHAERP

inhibition

phosphorylation

Ser314

DLEESSSsDHAERPP

inhibition

phosphorylation

Ser316

LEEEEENsDEDELDS

activation

phosphorylation

Ser328

ERALTEDsTQTSDTA

inhibition

phosphorylation

Ser329

LGGLCDLsSRY

inhibition

phosphorylation

Ser330

GGLCDLSsRY

inhibition

phosphorylation

Ser332

TEDSTQTsDTATNST

inhibition

phosphorylation

Ser357

REFCIPTsSNIEQQN

inhibition

phosphorylation

Ser357

RLPGSSDsRASASRA

inhibition

phosphorylation

Ser358

EFCIPTSsNIEQQNS

inhibition

phosphorylation

Ser363

RVTACTPsDGPGGGA

inhibition

phosphorylation

Ser366

EPIQMENsMGTLRTS

inhibition

phosphorylation

Ser373

SMGTLRTsISVERQI

inhibition

phosphorylation

Ser375

GTLRTSIsVERQIHK

inhibition

phosphorylation

Ser702

AVILTVEsEEEEEES

inhibition

phosphorylation

Ser709

SEEEEEEsDSSETEK

inhibition

phosphorylation

Ser711

EEEEESDsSETEKED

inhibition

phosphorylation

Ser712

EEEESDSsETEKEDD

inhibition

phosphorylation

Thr123

IVKCQKLtDDHVQFL

inhibition

phosphorylation

Thr312

RSQELRKtFKEIICC

inhibition

phosphorylation

Thr329

RALTEDStQTSDTAT

inhibition

phosphorylation

Thr331

LTEDSTQtSDTATNS

inhibition

phosphorylation

Thr334

DSTQTSDtATNSTLP

inhibition

phosphorylation

Thr336

TQTSDTAtNSTLPSA

inhibition

phosphorylation

Thr339

SDTATNStLPSAEVE

inhibition

phosphorylation

Thr356

FREFCIPtSSNIEQQ

inhibition

phosphorylation

Thr358

ATARERVtACTPSDG

inhibition

phosphorylation

Thr567

QGRDKYKtLRQIRQG

activation

phosphorylation

Thr62

PGMEGLGtDITVICP

activation

phosphorylation

Thr714

EESDSSEtEKEDDEG

inhibition

phosphorylation

Relations

Fatal error: Uncaught TypeError: implode(): Argument #2 ($array) must be of type ?array, string given in /home/prisca/signor/relation_result.php:2084 Stack trace: #0 /home/prisca/signor/relation_result.php(2084): implode() #1 {main} thrown in /home/prisca/signor/relation_result.php on line 2084

Regulator

Mechanism

target

score ℹ

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.2

Publications:

2

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

1

Organism:

In Vitro

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

1

Organism:

In Vitro

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

phosphorylation

0.2

Publications:

2

Organism:

Homo Sapiens