4.0
Summary
| Name |  GNAT1
|
| Full Name | Guanine nucleotide-binding protein G |
| Synonyms | Transducin alpha-1 chain | GNATR |
| Primary ID | P11488 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). |
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