Summary

Name ITGB6
Full Name Integrin beta-6
Synonyms ITB6_HUMAN
Primary ID P18564
Links - -
Type protein
Relations 6
Function Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding ITGB6 0.57
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ITGB6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB6 0.29
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Av/b6 integrin 0.862
Publications: 1
+ up-regulates activity img/indirect-activation.png PTK2 0.467
Publications: 1 Organism: Homo Sapiens