Summary

Name POLR2E
Full Name DNA-directed RNA polymerases I, II, and III subunit RPABC1
Synonyms RNA polymerases I, II, and III subunit ABC1, DNA-directed RNA polymerase II 23 kDa polypeptide, DNA-directed RNA polymerase II subunit E, RPB5 homolog, XAP4 |
Primary ID P19388
Links - -
Type protein
Relations 5
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ POLR2Eform complex img/form-complex.png binding RNA Polymerase I 0.917
Publications: 1
+ POLR2Eform complex img/form-complex.png binding RNA Polymerase III 0.884
Publications: 1 Organism: Homo Sapiens
+ POLR2Eform complex img/form-complex.png binding PAQosome co-chaperone complex 0.2
Publications: 1 Organism: Homo Sapiens
+ POLR2Eform complex img/form-complex.png binding RNA Polymerase II 0.889
Publications: 1 Organism: Homo Sapiens
+ GTF2F2up-regulates activity img/direct-activation.png binding POLR2E 0.917
Publications: 1 Organism: Chlorocebus Aethiops