Summary

Name TBP
Full Name TATA-box-binding protein
Synonyms TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit | GTF2D1, TF2D, TFIID
Primary ID P20226
Links - -
Type protein
Relations 11
Function General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding TFIIIB 0.834
Publications: 1
+ up-regulates activity img/direct-activation.png binding TBP 0.712
Publications: 1 Organism: Oryctolagus Cuniculus
+ down-regulates quantity img/direct_inhibition.png ubiquitination TBP 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBP 0.348
Publications: 1
+ up-regulates activity img/direct-activation.png binding TBP 0.9
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding SL1 complex 0.747
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBP 0.409
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding TFIID 0.892
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LIN28B 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TBP 0.398
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding TBP 0.4
Publications: 1 Organism: Homo Sapiens