Summary

Name CHRM3
Full Name Muscarinic acetylcholine receptor M3
Synonyms ACM3_HUMAN |
Primary ID P20309
Links - -
Type protein
Relations 26
Inhibitors aclidinium; solifenacin; oxybutynin; atropine; pirenzepine; Hexocyclium; tiotropium; dothiepin; amitriptyline
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.2
Publications: 2 Organism: Homo Sapiens, Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNA14 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png binding GNAQ 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM3 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM3 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNA15 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI3 0.14
Publications: 1 Organism: Homo Sapiens