Summary

Name TRH
Full Name Pro-thyrotropin-releasing hormone
Synonyms Pro-TRH, Prothyroliberin |
Primary ID P20396
Links - -
Type protein
Relations 3
Pathways Thyroid Hormone Metabolism
Function As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TRHR 0.753
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TRH 0.267
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:Thyroid Hormone Metabolism