| + |
IKBKB | down-regulates quantity by repression 
transcriptional regulation
|
COMT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251965 |
|
|
Homo sapiens |
Astrocytoma Cell |
| pmid |
sentence |
| 19291302 |
TNFα-dependent COMT downregulation was indeed mediated by the NF-κB pathway. Transient expression of p65, the essential component of NF-κB complexes, or IKKβ, the major positive regulator of NF-κB activition, significantly decreased P2-COMT reporter expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COMT | up-regulates quantity 
chemical modification
|
3-methoxytyramine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |dopamine is metabolized to 3-methoxytyramine by COMT, which is in turn converted to 3-methoxy-4-hydroxyacetaldehyde by MAO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
TNF | down-regulates quantity by repression
transcriptional regulation
|
COMT |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251963 |
|
|
Rattus norvegicus |
Astrocyte |
| pmid |
sentence |
| 19291302 |
COMT gene expression is downregulated by TNFα in primary rat astrocytes at both protein and mRNA levels. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
17beta-hydroxy-5alpha-androstan-3-one | up-regulates 
|
COMT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17612537 |
Catechol O-methyltransferase expression in granulosa cells was up-regulated by insulin, DHT, and ATRA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COMT | down-regulates quantity 
chemical modification
|
dopamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263997 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |dopamine is metabolized to 3-methoxytyramine by COMT, which is in turn converted to 3-methoxy-4-hydroxyacetaldehyde by MAO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
RELA | down-regulates quantity by repression
transcriptional regulation
|
COMT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251964 |
|
|
Homo sapiens |
Astrocytoma Cell |
| pmid |
sentence |
| 19291302 |
TNFα-dependent COMT downregulation was indeed mediated by the NF-κB pathway. Transient expression of p65, the essential component of NF-κB complexes, or IKKβ, the major positive regulator of NF-κB activition, significantly decreased P2-COMT reporter expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
tolcapone | down-regulates activity
chemical inhibition
|
COMT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258475 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26919286 |
The present work illustrates the potential therapeutic efficacy of COMT inhibition in alleviating cognitive impairment. A brain-penetrant COMT inhibitor, tolcapone, was tested in normal and phencyclidine-treated rats and COMT-Val transgenic mice. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261091 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9681662 |
Entacapone and tolcapone were powerful inhibitors of COMT and their IC50 estimates were 151 and 773 nM (P=0.008), respectively, in the liver; consistent results were obtained with the other tissues. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
INS | up-regulates quantity by expression
transcriptional regulation
|
COMT |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251961 |
|
|
Homo sapiens |
Granulosa Cell |
| pmid |
sentence |
| 17612537 |
Catechol O-methyltransferase expression in granulosa cells was up-regulated by insulin, DHT, and ATRA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
entacapone | down-regulates activity
chemical inhibition
|
COMT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258476 |
|
|
in vitro |
|
| pmid |
sentence |
| 7703232 |
Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at sufficiently high levels in Escherichia coli and in baculovirus-infected insect cells to allow kinetic characterization of the enzyme forms. The use of tight-binding inhibitors such as entacapone enabled the estimation of actual enzyme concentrations and, thereby, comparison of velocity parameters, substrate selectivity, and regioselectivity of the methylation of both enzyme forms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9681662 |
Entacapone and tolcapone were powerful inhibitors of COMT and their IC50 estimates were 151 and 773 nM (P=0.008), respectively, in the liver; consistent results were obtained with the other tissues. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| Tissue: |
Liver |
| + |
progesterone | down-regulates
|
COMT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251960 |
|
|
|
|
| pmid |
sentence |
| 17138778 |
Catechol-O-methyltransferase expression was down-regulated by progesterone or estrogen. |
|
| Publications: |
1 |
3.0
COMT
- 
- 