| + |
YAP1 | down-regulates 
|
MYF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199075 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
Myf6 (mrf4) is repressed by hyap1 s127a overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MYF6 | up-regulates quantity by expression 
transcriptional regulation
|
DES |
0.242 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241497 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8382796 |
Desmin, the muscle specific intermediate filament (IF) protein, is expressed at low levels in myoblasts and at the onset of differentiation its expression increases several fold. In an effort to explore the mechanism involved in the tissue-specific and developmentally regulated expression of desmin, we have isolated the mouse desmin gene.Co-transfection of myoD, myogenin, MRF4 and Myf5, with the desmin-CAT construct into 10T-1/2 cells demonstrated that all these factors could transactivate desmin gene expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYF6 | up-regulates 
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8288123 |
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop--helix (bhlh) motif that mediates dimerization and dna binding. / myogenic bhlh proteins form heterodimers with ubiquitous bhlh proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enhancers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
MYOG | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255642 |
|
|
|
|
| pmid |
sentence |
| 7739551 |
[...] confirming that myogenin binds to the E1 and E2 E boxes located in close proximity to the MRF4 transcription start site. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
MEF2D | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238715 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 7739551 |
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
CSRP3 | up-regulates activity
binding
|
MYF6 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241096 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9234731 |
we found that nuclear MLP functions through a physical interaction with the muscle basic helix-loop-helix (bHLH) transcription factors MyoD, MRF4, and myogenin. we propose that it serves as a cofactor for the myogenic bHLH proteins by increasing their interaction with specific DNA regulatory elements. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYF6 | up-regulates activity
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255645 |
|
|
|
|
| pmid |
sentence |
| 7532173 |
Finally, MRF4 may be responsible for the final myogenic events of the fully differentiated myofiber |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
MEF2A | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.592 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238709 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7739551 |
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238652 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 7739551 |
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
4.0
MYF6
- 
- 