Relation Results

Summary

Name Skeletal_muscle_differentiation
Primary ID SIGNOR-PH1
Type phenotype
Description The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle
Relations 25
Pathways NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, Thyroid Hormone Metabolism, WNT Signaling and Myogenesis

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Type: Score: Layout: SPV 
0.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.7MYOGSkeletal_muscle_differentiationCell_cycle_exitTDGF1EID3EZH2COX5BCCND1L-thyroxineIGFBP5MYF6TAF3/TRF3MAGED1SMAD3/SMAD4MYF5FLT3PAX73,3',5'-triiodothyronineMYOD1MEF2CPRDM16mTORC1TBX2

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Relations
Regulator
Mechanism
target
score ℹ
+ MYOGup-regulates activity img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255644
pmid sentence
These results suggest that at least initially, the muscle-forming regions contained cells with myogenic potential, and that this potential is lost in the myogenin mutants as development proceeds.
Publications: 1
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ Cell_cycle_exitup-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-243206 Mus musculus
pmid sentence
Myogenic precursor cells withdraw irreversibly from the cell cycle as they differentiate into mature myotubes. Cell cycle exit occurs early during the differentiation program and is required for normal expression of the contractile phenotype.
Publications: 1 Organism: Mus Musculus
+ TDGF1up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-192439 Homo sapiens Satellite Cell
pmid sentence
Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ MYOGup-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-37461 Homo sapiens
pmid sentence
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop--helix (bhlh) motif that mediates dimerization and dna binding. / myogenic bhlh proteins form heterodimers with ubiquitous bhlh proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enancers.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255112 Homo sapiens
pmid sentence
During early stages of myogenesis, CIITA binds directly to myogenin (MYOG) and inactivates it, preventing MYOG-mediated induction of myogenic genes that are required for muscle differentiation and function
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ EID3down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266641 Mus musculus
pmid sentence
Here we show that, when over-expressed, FRG1 binds and interferes with the activity of the histone methyltransferase Suv4-20h1 both in mammals and Drosophila. Accordingly, FRG1 over-expression or Suv4-20h1 knockdown inhibits myogenesis. The novel inhibitor of differentiation Eid3 is an FRG1/Suv4-20h1 target involved in the myogenic defects caused by FRG1 over-expression. Eid3 is down-regulated upon muscle differentiation and behaves as a myogenic inhibitor gene.
Publications: 1 Organism: Mus Musculus
+ EZH2down-regulates activity img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255719 Mus musculus
pmid sentence
We report that Ezh2 expression was developmentally regulated in the myotome compartment of mouse somites and that its down-regulation coincided with activation of muscle gene expression and differentiation of satellite-cell-derived myoblasts
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ COX5Bdown-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-253104 Mus musculus C2C12 Cell
pmid sentence
Together, these data suggest that R-cadherin expression inhibits myogenesis and induces myoblast transformation through Rac1 activation. Therefore, the properties of R-cadherin make it an attractive target for therapeutic intervention in RMS.
Publications: 1 Organism: Mus Musculus
+ CCND1down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255351 Homo sapiens
pmid sentence
Importantly, NF-kB can promote the expression and stability of cyclin D1 in muscle (4, 35, 39, 132), leading to increased cell proliferation and inhibition of differentiation.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ L-thyroxineup-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267620 Homo sapiens
pmid sentence
Skeletal muscle has been recognized as a key TH target for contractile function, regeneration, and transport as well as for metabolism and glucose disposal (237, 238). TH stimulation favors transition to fast-twitch fibers and transition to a faster myosin heavy chain (MHC) form.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ IGFBP5up-regulates activity img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255940 Mus musculus C2C12 Cell
pmid sentence
These findings suggest that IGFBP-5 promotes muscle cell differentiation by binding to and switching on the IGF-II auto-regulation loop.
Publications: 1 Organism: Mus Musculus
+ MYF6up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-37455 Homo sapiens
pmid sentence
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop--helix (bhlh) motif that mediates dimerization and dna binding. / myogenic bhlh proteins form heterodimers with ubiquitous bhlh proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enhancers.
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ TAF3/TRF3up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-237621 Mus musculus C2C12 Cell
pmid sentence
Here we report that differentiation of myoblast to myotubes involves the disruption of the canonical holo-TFIID and replacement by a novel TRF3/TAF3 (TBP-related factor 3/TATA-binding protein-associated factor 3) complex.
Publications: 1 Organism: Mus Musculus
+ MAGED1up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-166896 Homo sapiens Myoblast
pmid sentence
These data demonstrate for the first time that maged1 is an important factor required for proper skeletal myoblast differentiation and muscle healing.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SMAD3/SMAD4down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254989 Homo sapiens
pmid sentence
Taken together, these results suggest that myostatin inhibits MyoD activity and expression via Smad 3 resulting in the failure of the myoblasts to differentiate into myotubes
Publications: 1 Organism: Homo Sapiens
+ MYF5up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-37409 Homo sapiens
pmid sentence
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop--helix (bhlh) motif that mediates dimerization and dna binding. / myogenic bhlh proteins form heterodimers with ubiquitous bhlh proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enhancers.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling and Myogenesis
+ FLT3up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-202105 Homo sapiens Myoblast, Myofibroblast
pmid sentence
Here we report the identification of flt3l (fms-like tyrokine kinase 3 ligand) signaling as a novel regulator of skeletal myogenesis
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ MYF6up-regulates activity img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255645
pmid sentence
Finally, MRF4 may be responsible for the final myogenic events of the fully differentiated myofiber
Publications: 1
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ PAX7down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-219371 Homo sapiens
pmid sentence
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Satellite Cell
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ 3,3',5'-triiodothyronineup-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267619 Homo sapiens
pmid sentence
Skeletal muscle has been recognized as a key TH target for contractile function, regeneration, and transport as well as for metabolism and glucose disposal (237, 238). TH stimulation favors transition to fast-twitch fibers and transition to a faster myosin heavy chain (MHC) form.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ MYOD1up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-37458 Homo sapiens
pmid sentence
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop-helix (bHLH) motif that mediates dimerization and dna binding. [...] myogenic bHLH proteins form heterodimers with ubiquitous bHLH proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enhancers.
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ MEF2Cup-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-219368 Homo sapiens
pmid sentence
During embryogenesis, the MEF2 genes are expressed throughout developing skeletal and cardiac muscle lineages, as well as in the nervous system (19, 42, 65, 68).MEF2C is the first member of the family to be expressed in developing muscle cell lineages, with transcripts appearing in precardiac cells by about embryonic day 7.75 and in skeletal muscle precursor cells within the myotome of the developing somites by embryonic day 8.5. Soon thereafter, the other MEF2 genes are expressed in overlapping patterns (19). After birth, the expression of MEF2A, -B, and -Dbecomes ubiquitous, whereas the expression of MEF2C becomes restricted to skeletal muscle, brain, and spleen
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ PRDM16down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-180301 Homo sapiens Myoblast
pmid sentence
Loss of prdm16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation. Conversely, ectopic expression of prdm16 in myoblasts induces their differentiation into brown fat cells.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ mTORC1up-regulates activity img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256273 Mus musculus Satellite Cell
pmid sentence
Knockdown (KD) of either mTORC or its subunit Raptor delayed SC activation without influencing the differentiation program.
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid Hormone Metabolism
+ TBX2down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-251563 Homo sapiens
pmid sentence
TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
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