3.0
Summary
| Name |  PTPRZ1View Modifications |
| Full Name | Receptor-type tyrosine-protein phosphatase zeta |
| Synonyms | R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2 | HTPZP2, PTPRZ, PTPRZ2, PTPZ |
| Primary ID | P23471 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PTPRZ1 | down-regulates activity 
dephosphorylation
|
ARHGAP35 | 0.427 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | EPAS1 | up-regulates quantity by expression 
transcriptional regulation
|
PTPRZ1 | 0.266 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPRZ1 | up-regulates activity 
dephosphorylation
|
CTNNB1 | 0.386 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPRZ1 | down-regulates
dephosphorylation
|
ALK | 0.561 |
| Publications: | 1 | Organism: | Homo Sapiens | |