Relation Results

Summary

Name ARHGAP35
Full Name Rho GTPase-activating protein 35
Synonyms Glucocorticoid receptor DNA-binding factor 1, Glucocorticoid receptor repression factor 1, GRF-1, Rho GAP p190A, p190-A | GRF1, GRLF1, KIAA1722
Primary ID Q9NRY4
Links - -
Type protein
Relations 10
Function Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to prom ...
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Type: Score: Layout: SPV 
0.4230.7630.4270.20.890.713ROCK1ARHGAP35SRCPTPRZ1TRIM65RHOARAC1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ROCK1down-regulates img/direct_inhibition.png phosphorylation ARHGAP35 0.423
Identifier Residue Sequence Organism Cell Line
SIGNOR-182849 Ser1150 LERGRKVsIVSKPVL Homo sapiens
pmid sentence
Rho-kinase, an effector of rhoa, phosphorylated p190a rhogap at ser(1150) and attenuated p190a rhogap activity in cos7 cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-182853 Ser1236 PKPKPRPsITKATWE Homo sapiens
pmid sentence
Here we show that rho-kinase, an effector of rhoa, phosphorylated p190a rhogap at ser1150 and attenuated p190a rhogap activity in cos7 cells
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ ROCK1down-regulates activity img/direct_inhibition.png phosphorylation ARHGAP35 0.423
Identifier Residue Sequence Organism Cell Line
SIGNOR-276177 Ser1150 LERGRKVsIVSKPVL Chlorocebus aethiops COS-7 Cell
pmid sentence
these results indicate that Rho-kinase can phosphorylate p190A RhoGAP at Ser1150 in COS7 cells. Similarly, the immunoblot analysis, through the use of the anti-p190A RhoGAP-pT1226 and -pS1236 antibodies, revealed that Rho-kinase can phosphorylate p190A RhoGAP at Thr1226 and Ser1236 in COS7 cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-276176 Ser1236 PKPKPRPsITKATWE Chlorocebus aethiops COS-7 Cell
pmid sentence
these results indicate that Rho-kinase can phosphorylate p190A RhoGAP at Ser1150 in COS7 cells. Similarly, the immunoblot analysis, through the use of the anti-p190A RhoGAP-pT1226 and -pS1236 antibodies, revealed that Rho-kinase can phosphorylate p190A RhoGAP at Thr1226 and Ser1236 in COS7 cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-276178 Thr1226 LRSLRRNtKKPKPKP Chlorocebus aethiops COS-7 Cell
pmid sentence
these results indicate that Rho-kinase can phosphorylate p190A RhoGAP at Ser1150 in COS7 cells. Similarly, the immunoblot analysis, through the use of the anti-p190A RhoGAP-pT1226 and -pS1236 antibodies, revealed that Rho-kinase can phosphorylate p190A RhoGAP at Thr1226 and Ser1236 in COS7 cells
Publications: 3 Organism: Chlorocebus Aethiops
+ SRCup-regulates img/direct-activation.png phosphorylation ARHGAP35 0.763
Identifier Residue Sequence Organism Cell Line
SIGNOR-61670 Tyr1105 RNEEENIySVPHDST Homo sapiens
pmid sentence
Phosphorylation of y1105, but not the minor site, was modulated in vivo to a greater extent by overexpression of c-src than by the egf receptor and was efficiently catalyzed by c-src in vitro. Mutation of y1105 from tyr to phe resulted in complete loss of p-tyr-dependent complex formation, indicating that p-y1105 was the sole p-tyr residue mediating binding to p120
Publications: 1 Organism: Homo Sapiens
+ PTPRZ1down-regulates activity img/direct_inhibition.png dephosphorylation ARHGAP35 0.427
Identifier Residue Sequence Organism Cell Line
SIGNOR-248451 Tyr1105 RNEEENIySVPHDST Mus musculus Hippocampus
pmid sentence
Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP| Furthermore, Ptprz selectively dephosphorylated pY1105 of p190 RhoGAP in vitro, and the tyrosine phosphorylation at Y1105 controls p190 RhoGAP activity in vivo.
Publications: 1 Organism: Mus Musculus
+ TRIM65down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ARHGAP35 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272256 Homo sapiens KM-12 Cell
pmid sentence
Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation
Publications: 1 Organism: Homo Sapiens
+ ARHGAP35down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.89
Identifier Residue Sequence Organism Cell Line
SIGNOR-260492 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ ARHGAP35down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.713
Identifier Residue Sequence Organism Cell Line
SIGNOR-260493 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
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