| + |
GADD45A | down-regulates 
binding
|
CDK1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10362260 |
Gadd45 has now been found to directly inhibit the activity of cdc2/cyclin b1 complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GADD45A | down-regulates activity
binding
|
CDK11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273023 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
GADD45alpha inhibits CDK11p58 kinase activity|We identified CDK11p58 as an interaction partner of GADD45α by co-immunoprecipitation analysis. We corroborated these data by co-immunoprecipitation in vitro translation assays, showing that all three members of the GADD45 family interact with CDK11p58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GADD45A | down-regulates
binding
|
MAPK14 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134333 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15735649 |
Both phosphorylation of p38 ty323 and the activity of this phosphorylated species are inhibited by binding gadd45alpha, thus preventing these low-treshold signals from activating p38 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Gadd45alfa appears to act as an endogenous inhibitor of the alternative p38alfa-activation pathway in t-cell, by binding to p38alfa and preventing tyr323 phosphorilation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HNRNPU | up-regulates quantity by stabilization 
post transcriptional regulation
|
GADD45A |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262282 |
|
|
|
|
| pmid |
sentence |
| 17174306 |
In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor alpha mRNA by increasing its stability, possibly through binding to the 3' untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. |
|
| Publications: |
1 |
| + |
GADD45A | down-regulates
binding
|
CyclinB/CDK1 |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217508 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10362260 |
Gadd45 has now been found to directly inhibit the activity of cdc2/cyclin b1 complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | up-regulates quantity by expression
transcriptional regulation
|
GADD45A |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23576563 |
P53 acetylated at k120 subsequently bound to the promoters of its target apoptotic genes, bax and gadd45, to promote their expression and lead to apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GADD45A
- 
- 