4.0
Summary
| Name |  AKAP5View Modifications |
| Full Name | A-kinase anchor protein 5 |
| Synonyms | AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein | AKAP79 |
| Primary ID | P24588 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ZDHHC2 | up-regulates activity 
palmitoylation
|
AKAP5 | 0.333 |
| Publications: | 2 | Organism: | Rattus Norvegicus | |
| + | AKAP5 | up-regulates activity
relocalization
|
PRKACA | 0.558 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | AKAP5 | up-regulates activity
relocalization
|
PPP3CC | 0.262 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |