| + |
CD40LG | up-regulates activity 
binding
|
CD40 |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93432 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12324477 |
Ramos cells were mixed with increasing numbers of transfected cells that expressed cd70 (cd27l) or cd154 (cd40l), both of which are expressed by activated T cells, in the presence of anti-igm ab. Cd27 ligation as well as cd40 ligation inhibited bcr-mediated apoptosis in a dose-dependent manner. cd40 binds its ligand cd40l. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185660 |
|
|
Homo sapiens |
T-lymphocyte, RAMOS Cell |
| pmid |
sentence |
| 19426221 |
Ramos cells were mixed with increasing numbers of transfected cells that expressed cd70 (cd27l) or cd154 (cd40l), both of which are expressed by activated t cells, in the presence of anti-igm ab. Cd27 ligation as well as cd40 ligation inhibited bcr-mediated apoptosis in a dose-dependent manner .cd40 binds its ligand cd40l. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
CD40 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254785 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19164127 |
We found that upon TLR7 and TLR8 activation, JNK and NF-kappaB positively regulated the expression of CCR7, CD86, CD83, and CD40 and the production of IL-6 and IL-12p40. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
CD40 | up-regulates quantity by expression
transcriptional regulation
|
BIK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93390 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12324477 |
Bik expression was weakly but significantly down-regulated by cd27 but up-regulated by cd40. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD40 | up-regulates activity
binding
|
TRAF2 |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179473 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 18635759 |
Cd40, a tumor necrosis factor receptor (tnfr) family member, forms a complex containing adaptor molecules traf2 and traf3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis, NF-KB Non Canonical |
| + |
sirolimus | down-regulates quantity by repression 
transcriptional regulation
|
CD40 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18652845 |
Although RAPA downregulated ILT2, ILT3 and ILT4 expression in DC, the inhibition of T cell proliferation by RAPA-treated DC is predominantly due to the reduction of CD40, CD80 and CD86 expression rather than the propensity to generate FoxP3 expressing regulatory cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD40 | up-regulates quantity by expression
transcriptional regulation
|
BCL2L1 |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93387 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12324477 |
Cd40 ligation up-regulated bcl-2 and bcl-xl as much as 9.7- (p < 0.01) and 6.8-fold (p < 0.01), respectively (fig. 2, b and c). Under similar conditions, cd27 ligation also up-regulated bcl-2 and bcl-xl as much as 5.0- (p < 0.01) and 3.9-fold (p < 0.01), respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD40 | up-regulates activity
binding
|
TRAF3 |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18635759 |
Cd40, a tumor necrosis factor receptor (tnfr) family member, forms a complex containing adaptor molecules traf2 and traf3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
CD40 | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189109 |
|
|
Homo sapiens |
T-lymphocyte, B-lymphocyte |
| pmid |
sentence |
| 19904719 |
Cd40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including t cell-dependent immunoglobulin class switching, memory b cell development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
3.0
CD40
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- 