Relation Results

Summary

Name	TRAF3 View Modifications
Full Name	TNF receptor-associated factor 3
Synonyms	CAP-1, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, LMP1-associated protein 1, LAP1 \| CAP1, CRAF1
Primary ID	Q13114
Links	- -
Type	protein
Relations	17
Pathways	COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Monocyte: IL10 transcriptional regulation, NF-KB Non Canonical, SARS-CoV INFLAMMATORY RESPONSE
Function	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

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▶Modifications Tables

Relations

Regulator

Mechanism

target

score ℹ

up-regulates activity img/direct-activation.png

img/direct-activation.png

phosphorylation

0.311

Publications:

3

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

dephosphorylation

0.2

Publications:

2

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.916

Publications:

1

Organism:

Homo Sapiens

Pathways:

NF-KB Non Canonical

Papain-like proteinase

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

deubiquitination

0.2

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.9

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

binding

0.443

Publications:

1

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

binding

0.654

Publications:

1

Organism:

Mus Musculus

Pathways:

Innate Immune Response, NF-KB Non Canonical

down-regulates quantity by destabilization img/indirect_inhibition.png

img/indirect_inhibition.png

0.2

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

binding

0.749

Publications:

1

Organism:

Homo Sapiens

Pathways:

NF-KB Non Canonical

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

binding

0.479

Publications:

1

up-regulates quantity by expression img/indirect-activation.png

img/indirect-activation.png

transcriptional regulation

0.337

Publications:

1

Organism:

Mus Musculus

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

deubiquitination

0.767

Publications:

1

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.717

Publications:

1

Organism:

Mus Musculus

Pathways:

COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE

up-regulates activity img/direct-activation.png

img/direct-activation.png

ubiquitination

0.2

Publications:

1

Organism:

Homo Sapiens