| + |
MAP3K7 |
phosphorylation
|
PTPN3 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52781 |
Ser359 |
PAMRRSLsVEHLETK |
Homo sapiens |
|
| pmid |
sentence |
| 9341175 |
Mutation of ser359 and ser853 to alanine significantly reduced the association between 14-3-3beta and ptph1. Furthermore, association of ptph1 and 14-3-3beta was detected in several cell lines and was regulated in response to extracellular signals |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN3 | down-regulates activity 
dephosphorylation
|
GHR |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248459 |
Tyr534 |
NFLMDNAyFCEADAK |
Cricetulus griseus |
|
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
PTPN3 | up-regulates activity 
dephosphorylation
|
ESR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277127 |
Tyr537 |
CKNVVPLyDLLLEML |
Homo sapiens |
|
| pmid |
sentence |
| 26079946 |
Our recent studies further demonstrated that PTPH1 dephosphorylates estrogen receptor at Y537, increases estrogen receptor stability and nuclear accumulation, and enhances breast cancer sensitivity to anti-estrogens [ ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN3 | down-regulates activity
dephosphorylation
|
VCP |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248460 |
Tyr796 |
GGTGGSVyTEDNDDD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10364224 |
Identification of VCP as a substrate of PTPH1in vivo.|The tyrosines (Tyr796 and Tyr805) at the C terminus of VCP have been reported to be the major sites of phosphorylation, with Tyr805 accounting for more than 90% of the tyrosine phosphorylation on the protein |The Y796F/Y805F VCP mutant was not associated with any of the PTPH1 constructs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248461 |
Tyr805 |
EDNDDDLyG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10364224 |
Identification of VCP as a substrate of PTPH1in vivo.|The tyrosines (Tyr796 and Tyr805) at the C terminus of VCP have been reported to be the major sites of phosphorylation, with Tyr805 accounting for more than 90% of the tyrosine phosphorylation on the protein |The Y796F/Y805F VCP mutant was not associated with any of the PTPH1 constructs. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
PTPN3
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