Summary

Name MAP3K7
Full Name Mitogen-activated protein kinase kinase kinase 7
Synonyms Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1 | TAK1
Primary ID O43318
Links - -
Type protein
Relations 75
Pathways COVID-19 Causal Network, IBD_DENDRITIC CELLS, EBV infection, FAP: BMP, FAP: TGF beta, iCAF signaling in PDAC, IBD_IEC, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage: IL1 beta, Macrophage: TNF alpha, NF-KB Canonical, Osteoblast: BMP, Osteoblast: TGF beta, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Satellite: IL1 , SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity).

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations


Fatal error: Uncaught TypeError: implode(): Argument #2 ($array) must be of type ?array, string given in /home/prisca/signor/relation_result.php:2084 Stack trace: #0 /home/prisca/signor/relation_result.php(2084): implode() #1 {main} thrown in /home/prisca/signor/relation_result.php on line 2084
Regulator Mechanism target score ℹ
+ TRIM8up-regulates activity img/direct-activation.png polyubiquitination MAP3K7 0.335
Publications: 1
+ TRAF2up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.612
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, SAPK/JNK Signaling
+ TRAF6up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.895
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, NF-KB Canonical, P38 Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors
+ MAP3K7down-regulates activity img/direct_inhibition.png phosphorylation YAP1 0.335
Publications: 1 Organism: Homo Sapiens
+ MAP3K7down-regulates img/direct_inhibition.png phosphorylation HDAC7 0.2
Publications: 1 Organism: Homo Sapiens
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation IKBKB 0.762
Publications: 3 Organism: Homo Sapiens
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation MAP3K7 0.2
Publications: 5 Organism: In Vitro, Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation ATAT1 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation RASSF9 0.2
Publications: 1 Organism: Homo Sapiens
+ MAP3K7down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TNFAIP8L2 0.2
Publications: 1 Organism: Homo Sapiens
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation STING1 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network
+ MAP3K7