| + |
PTPN2 | down-regulates activity 
dephosphorylation
|
GHR |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248391 |
Tyr332 |
ILAIHDSyKPEFHSD |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248392 |
Tyr487 |
SLSNIDFyAQVSDIT |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248393 |
Tyr534 |
NFLMDNAyFCEADAK |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248394 |
Tyr566 |
SLNQEDIyITTESLT |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Publications: |
4 |
Organism: |
Cricetulus Griseus |
| + |
PTPN1 | down-regulates activity
dephosphorylation
|
GHR |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248418 |
Tyr332 |
ILAIHDSyKPEFHSD |
Cricetulus griseus |
|
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248419 |
Tyr487 |
SLSNIDFyAQVSDIT |
Cricetulus griseus |
|
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248420 |
Tyr534 |
NFLMDNAyFCEADAK |
Cricetulus griseus |
|
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248421 |
Tyr566 |
SLNQEDIyITTESLT |
Cricetulus griseus |
|
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Publications: |
4 |
Organism: |
Cricetulus Griseus |
| + |
PTPN3 | down-regulates activity
dephosphorylation
|
GHR |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248459 |
Tyr534 |
NFLMDNAyFCEADAK |
Cricetulus griseus |
|
| pmid |
sentence |
| 12907755 |
PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
GH1 | up-regulates 
binding
|
GHR |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7862673 |
The hghr only binds primate gh. Arg43 in hghr interacts with asp171 of hgh. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates
dephosphorylation
|
GHR |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12907755 |
Inally, mrna tissue distribution of these ptps by rt-pcr analysis and coexpression of the wild-type ptps to test their ability to dephosphorylate ligand-activated ghr suggest ptp-h1 and ptp1b as potential candidates involved in ghr signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN9 | down-regulates activity
dephosphorylation
|
GHR |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248505 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (GHR) intracellular domain. Among 31 PTPs tested, T cell (TC)-PTP, PTP-beta, PTP1B, stomach cancer-associated PTP 1 (SAP-1), Pyst-2, Meg-2, and PTP-H1 showed specificity for phosphorylated GHR |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
GHR | up-regulates 
|
NFATC2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23612709 |
Activated NFATc2 stimulates myoblast fusion through the increased production of IL-4 and myoferlin. Possible stimuli for NFATc2 activation are PGF2α and GH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GHR | up-regulates activity
phosphorylation
|
MAP2K5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255452 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
DUSP7 | down-regulates activity
dephosphorylation
|
GHR |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248726 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (GHR) intracellular domain. Among 31 PTPs tested, T cell (TC)-PTP, PTP-beta, PTP1B, stomach cancer-associated PTP 1 (SAP-1), Pyst-2, Meg-2, and PTP-H1 showed specificity for phosphorylated GHR |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
PTPN9 | down-regulates
dephosphorylation
|
GHR |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12907755 |
Using ghr hyper-phosphorylated by elk kinase, we have identified tc-ptp, ptp- , pyst-2, sap1, meg-2, ptp1b, and ptph1 as having substrate specificity for this receptor. In addition, we have shown that these same ptps (or rather their nonmutated counterparts) can dephosphorylate the ghr. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP7 | down-regulates
dephosphorylation
|
GHR |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104545 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12907755 |
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates activity
binding
|
GHR |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7862673 |
Although growth hormone (GH) receptors (GHRs) in many species bind human (h) GH as well as their own GH, the hGHR only binds primate GH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRH | down-regulates activity
dephosphorylation
|
GHR |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248802 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12907755 |
Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (GHR) intracellular domain. Among 31 PTPs tested, T cell (TC)-PTP, PTP-beta, PTP1B, stomach cancer-associated PTP 1 (SAP-1), Pyst-2, Meg-2, and PTP-H1 showed specificity for phosphorylated GHR |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
3.0
GHR
- 
- 