| + |
KLKB1 | up-regulates activity 
cleavage
|
MST1 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256511 |
Arg483 |
DQRRSKLrVVGGHPG |
in vitro |
|
| pmid |
sentence |
| 10068459 |
Proteolytic cleavage of pro-MSP at a single site yields active MSP, a disulfide-linked alphabeta-chain heterodimer. human kallikrein cleaved only at Arg483–Val484, the cleavage site for formation of a- and b-chains. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MST1 |
phosphorylation
|
H2BC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171005 |
Ser15 |
APAPKKGsKKAITKA |
Homo sapiens |
|
| pmid |
sentence |
| 21212262 |
The mst1 is a serine/threonine kinase that is activated upon apoptotic stimulation, which in turn activates its downstream targets, jnk/p38, histone h2b and foxo. Mst1 induces apoptosis by phosphorylating histone h2b on a relatively conserved site, ser-14 in mammalian cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MST1 | up-regulates activity
phosphorylation
|
PRKCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277179 |
Ser226 |
LNPQWNEsFTFKLKP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26414765 |
Thus, the phosphorylation of PKCα at Ser226 and Thr228 by Mst1 and Mst2 is required for the optimal activation of PKCα. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277178 |
Thr228 |
PQWNESFtFKLKPSD |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26414765 |
Thus, the phosphorylation of PKCα at Ser226 and Thr228 by Mst1 and Mst2 is required for the optimal activation of PKCα. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MST1 | up-regulates
phosphorylation
|
STK4 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114289 |
Thr183 |
DTMAKRNtVIGTPFW |
Homo sapiens |
|
| pmid |
sentence |
| 11805089 |
We directly show that okadaic acid induces phosphorylation in the activation loop of mst, and, once phosphorylated, mst is rapidly translocated to the nucleus. when thr183 in mst1 was mutated to ala, no band could be detected by oa treatment,2 indicating that thr183 was the site of phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MST1 | up-regulates
binding
|
MST1R |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31107 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8062829 |
P185ron is a tyrosine kinase activated by msp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MST1
- 
- 