| + |
CNTF | up-regulates 
binding
|
CNTFR |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77408 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10812968 |
Signal transduction by cntf requires that it bind first to cntfr alpha. Cntf activates downstream signaling molecules |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10966616 |
Ciliary neurotrophic factor (cntf) is a cytokine supporting the differentiation and survival of various cell types in the peripheral and central nervous systems. Its receptor complex consists of a non-signaling alpha chain, cntfr, and two signaling beta chains, gp130 and the leukemia inhibitory factor receptor (lifr) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CNTFR | up-regulates 
|
STAT1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10582086 |
Signal transduction by cntf requires that it bind first to cntfr alpha, permitting the recruitment of gp130 and lifr beta, forming a tripartite receptor complex. Cntf-induced heterodimerization of the beta receptor subunits leads to tyrosine phosphorylation (through constitutively associated jaks), and the activated receptor provides docking sites for sh2-containing signaling molecules, such as stat proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTFR | up-regulates
|
STAT3 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10582086 |
Clc/clf activates stat1 and stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLCF1 | up-regulates
binding
|
CNTFR |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81376 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10966616 |
Striking phenotypic differences between cntf- and cntfr-deficient mice suggest that cntfr serves as a receptor for a second, developmentally important ligand. We have identified this factor as a stable secreted complex of cardiotrophin-like cytokine (clc) and the soluble receptor cytokine-like factor-1 (clf). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CNTFR
- 
- 