| + |
CNTF | up-regulates 
binding
|
IL6ST |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47991 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTF | up-regulates
binding
|
CRLF1 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11294841 |
We recently demonstrated that cardiotrophin-like cytokine (clc) associates with the soluble orphan receptor cytokine-like factor-1 (clf) to form a heterodimeric cytokine that displayed activities only on cells expressing the tripartite cntf receptor on their surface |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTF | up-regulates
binding
|
CNTFR |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10966616 |
Ciliary neurotrophic factor (cntf) is a cytokine supporting the differentiation and survival of various cell types in the peripheral and central nervous systems. Its receptor complex consists of a non-signaling alpha chain, cntfr, and two signaling beta chains, gp130 and the leukemia inhibitory factor receptor (lifr) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77408 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10812968 |
Signal transduction by cntf requires that it bind first to cntfr alpha. Cntf activates downstream signaling molecules |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CNTF | up-regulates
binding
|
LIFR |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10966616 |
Ciliary neurotrophic factor (cntf) is a cytokine supporting the differentiation and survival of various cell types in the peripheral and central nervous systems. Its receptor complex consists of a non-signaling alpha chain, cntfr, and two signaling beta chains, gp130 and the leukemia inhibitory factor receptor (lifr) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CNTF
- 
- 