3.0
Summary
| Name |  ELK4View Modifications |
| Full Name | ETS domain-containing protein Elk-4 |
| Synonyms | Serum response factor accessory protein 1, SAP-1, SRF accessory protein 1 | SAP1 |
| Primary ID | P28324 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK2 | up-regulates activity 
phosphorylation
|
ELK4 | |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PCSK7 | up-regulates
phosphorylation
|
ELK4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ELK4 | up-regulates quantity by expression
transcriptional regulation
|
INSIG2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |