| + |
PAK4 | up-regulates activity 
phosphorylation
|
MZF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277422 |
Ser27 |
VMVKLEDsEEEGEAA |
in vitro |
|
| pmid |
sentence |
| 30622337 |
Here, we link ErbB2 activation to invasion via ErbB2-induced, SUMO-directed phosphorylation of a single serine residue, S27, of the transcription factor myeloid zinc finger-1 (MZF1). Phosphorylation of MZF1-S27 is an early response to ErbB2 activation and results in increased transcriptional activity of MZF1.The phosphorylation of MZF1-S27 is preceded by poly-SUMOylation of K23, which can make S27 accessible to efficient phosphorylation by PAK4. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MZF1 | up-regulates quantity by expression 
transcriptional regulation
|
CCN2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25899830 |
we report the regulation of the CTGF and NOV genes by Myeloid Zinc Finger-1 (MZF-1), a hematopoietic transcription factor. We show the interaction of MZF-1 with the CTGF and NOV promoters in several cell types. Up-regulation of MZF-1 via calcitriol and vitamin A induces expression of CTGF and NOV, implicating a role for these vitamins in the functions of these two genes. Lastly, knockdown of MZF1 reduces levels of CTGF and NOV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MZF1 | up-regulates quantity by expression
transcriptional regulation
|
CCN3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25899830 |
we report the regulation of the CTGF and NOV genes by Myeloid Zinc Finger-1 (MZF-1), a hematopoietic transcription factor. We show the interaction of MZF-1 with the CTGF and NOV promoters in several cell types. Up-regulation of MZF-1 via calcitriol and vitamin A induces expression of CTGF and NOV, implicating a role for these vitamins in the functions of these two genes. Lastly, knockdown of MZF1 reduces levels of CTGF and NOV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MZF1 | up-regulates quantity by expression
transcriptional regulation
|
PRKCA |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256283 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16297876 |
We demonstrated that both Elk-1 and MZF-1 were highly expressed in human poor differentiated HCC cells and involved in the up-regulation of PKCa, which was essential for cell migration and invasion. Over-expression assay confirmed that the PKCa expression may be modulated by these two factors at the transcriptional level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MZF1 | up-regulates quantity by expression
transcriptional regulation
|
PRKCA |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26010542 |
The luciferase reporter assay results revealed that the presence of both MZF-1 and Elk-1 significantly contributed to the upregulation of PKCα gene transcription activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCAND1 | up-regulates activity
binding
|
MZF1 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221561 |
|
|
in vitro |
|
| pmid |
sentence |
| 10777584 |
Co-immunoprecipitation and yeast two-hybrid analyses demonstrate that MZF1B and RAZ1 associate in vitro via a SCAN box-dependent mechanism. The interaction between MZF1B and RAZ1 might be necessary for mediating MZF1B function |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
MZF1
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- 