Relation Results

Summary

Name MZF1
Full Name Myeloid zinc finger 1
Synonyms MZF-1, Zinc finger and SCAN domain-containing protein 6, Zinc finger protein 42 | MZF, ZNF42, ZSCAN6
Primary ID P28698
Links - -
Type protein
Relations 6
Function Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator ...
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Type: Score: Layout: SPV 
0.20.3920.20.3720.2PAK4MZF1PRKCACCN2SCAND1CCN3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PAK4up-regulates activity img/direct-activation.png phosphorylation MZF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277422 Ser27 VMVKLEDsEEEGEAA in vitro
pmid sentence
 Here, we link ErbB2 activation to invasion via ErbB2-induced, SUMO-directed phosphorylation of a single serine residue, S27, of the transcription factor myeloid zinc finger-1 (MZF1).  Phosphorylation of MZF1-S27 is an early response to ErbB2 activation and results in increased transcriptional activity of MZF1.The phosphorylation of MZF1-S27 is preceded by poly-SUMOylation of K23, which can make S27 accessible to efficient phosphorylation by PAK4.
Publications: 1 Organism: In Vitro
+ MZF1up-regulates quantity by expression img/direct-activation.png transcriptional regulation PRKCA 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-256337 Homo sapiens
pmid sentence
The luciferase reporter assay results revealed that the presence of both MZF-1 and Elk-1 significantly contributed to the upregulation of PKCα gene transcription activity.
Publications: 1 Organism: Homo Sapiens
+ MZF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-226307 Homo sapiens
pmid sentence
we report the regulation of the CTGF and NOV genes by Myeloid Zinc Finger-1 (MZF-1), a hematopoietic transcription factor. We show the interaction of MZF-1 with the CTGF and NOV promoters in several cell types. Up-regulation of MZF-1 via calcitriol and vitamin A induces expression of CTGF and NOV, implicating a role for these vitamins in the functions of these two genes. Lastly, knockdown of MZF1 reduces levels of CTGF and NOV.
Publications: 1 Organism: Homo Sapiens
+ SCAND1up-regulates activity img/direct-activation.png binding MZF1 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-221561 in vitro
pmid sentence
Co-immunoprecipitation and yeast two-hybrid analyses demonstrate that MZF1B and RAZ1 associate in vitro via a SCAN box-dependent mechanism. The interaction between MZF1B and RAZ1 might be necessary for mediating MZF1B function
Publications: 1 Organism: In Vitro
+ MZF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCN3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-226356 Homo sapiens
pmid sentence
we report the regulation of the CTGF and NOV genes by Myeloid Zinc Finger-1 (MZF-1), a hematopoietic transcription factor. We show the interaction of MZF-1 with the CTGF and NOV promoters in several cell types. Up-regulation of MZF-1 via calcitriol and vitamin A induces expression of CTGF and NOV, implicating a role for these vitamins in the functions of these two genes. Lastly, knockdown of MZF1 reduces levels of CTGF and NOV.
Publications: 1 Organism: Homo Sapiens
+ MZF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PRKCA 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-256283 Homo sapiens
pmid sentence
We demonstrated that both Elk-1 and MZF-1 were highly expressed in human poor differentiated HCC cells and involved in the up-regulation of PKCa, which was essential for cell migration and invasion. Over-expression assay confirmed that the PKCa expression may be modulated by these two factors at the transcriptional level.
Publications: 1 Organism: Homo Sapiens
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